Klinik für Augenheilkunde

Research focus

Restoring corneal transparency represents the basis for precise optics. For this purpose, corneal donation is an invaluable and generous gift. Starting in the field of eye banking and extending over corneal transplantation methods up to patient care is a challenging and highly topical task. 

Objective

Actually, the field of keratoplasty is rapidly evolving. It is crucial to gain evidence for well adapted donor selection, evaluation and preparation. This builds the basis for as well established and new keratoplasty techniques. Especially the lamellar techniques show a big potential for standardization and optimization. 

Projects

1. Influences on and outcomes of penetrating and lamellar keratoplasty techniques: Gaining insights into clinically relevant factors contributing to optimized visual acuity and quality of life for the patients
2. New methods in modern eye banking: Artificial intelligence improves the technical basis for precise evaluation of the donor corneas quality parameters 

Selected publications

1. Influences on and outcomes of penetrating and lamellar keratoplasty techniques
   • Influence of Postoperative Intraocular Pressure on Graft Detachment After Descemet Membrane Endothelial Keratoplasty.

     Heinzelmann S, Böhringer D, Haverkamp C, Lapp T, Eberwein P, Reinhard T, Maier P.

     Cornea. 2018 Nov;37(11):1347-1350. doi: 10.1097/ICO.0000000000001677.

   • Outcomes of Descemet membrane endothelial keratoplasty, Descemet stripping automated endothelial keratoplasty and penetrating keratoplasty from a single centre study.

     Heinzelmann S, Böhringer D, Eberwein P, Reinhard T, Maier P.

     Graefes Arch Clin Exp Ophthalmol. 2016 Mar;254(3):515-22. doi: 10.1007/s00417-015-3248-z. Epub 2016 Jan 7.

   • Cystoid macular oedema following Descemet membrane endothelial keratoplasty.

     Heinzelmann S, Maier P, Böhringer D, Hüther S, Eberwein P, Reinhard T.

     Br J Ophthalmol. 2015 Jan;99(1):98-102. doi: 10.1136/bjophthalmol-2014-305124. Epub 2014 Aug 19.

   • Influence of donor characteristics on descemet membrane endothelial keratoplasty.

     Heinzelmann S, Hüther S, Böhringer D, Eberwein P, Reinhard T, Maier P.

     Cornea. 2014 Jun;33(6):644-8. doi: 10.1097/ICO.0000000000000106.

2. New methods in modern eye banking
   • [Automated Cell Counting Using "Deep Learning" in Donor Corneas from Organ Culture Achieves High Precision and Accuracy].

     Heinzelmann S, Daniel MC, Maier PC, Reinhard T, Böhringer D.

     Klin Monbl Augenheilkd. 2019 Dec;236(12):1407-1412. doi: 10.1055/a-1023-4339. Epub 2019 Dec 5. German.