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Arbeitsgruppe Lübke

Research focus

In glaucoma, the focus from an ophthalmologic point of view is the optimal adjustment of intraocular pressure. This can be done by eye drops, laser treatments or surgical procedures. A frequent complication after surgical procedures is scarring of the created outflow path for the aqueous humor, through which the intraocular pressure should be regulated. 

A variety of different factors play a role in scarring. Our research focuses on identifying and precisely describing these factors. Thus, potential approaches to improve wound healing after glaucoma surgery should be found.

Another research focus is the direct modulation of scarring after filtering surgical procedures such as trabeculectomy by using novel surface polymers to influence and optimize the created wound surfaces.  

The findings of this work are to be transferred to clinical research within the framework of translational projects and applied there.

Projects and selected publications

  1. Surface coating with a polymer to prevent tenon fibroblasts from scleral attaching
    • Prevention of Ocular Tenon Adhesion to Sclera by a PDMAA Polymer to Improve Results after Glaucoma Surgery. Martin G & Lübke J, Schefold S, Jordan JF, Schlunck G, Reinhard T, Kanokwijitsilp T, Prucker O, Rühe J, Anton A. Macromolecular Rapid Communications, 01/2020, DOI: 10.1002/marc.201900352
    • Photogenerated Surface-Attached Polymer Networks through C-H-Insertion Crosslinking Kanokwijitsilp T, Körner M, Lübke J, Prucker O, Anton A, Rühe J. Macromolecules, 2021, DOI: 10.1201/acs.macromol.1c00121
  2. Transdifferentiation of tenon fibroblasts
    • Collaboration with AG Schlunck / Dr. Wiedenmann to identify factors influencing the transdifferentiation of tenon fibroblasts to scar-forming tissue and finding potential therapeutic approaches on this.
  3. Evaluation of pressure-lowering procedures in clinical practice with regard to long-term courses and complicated cases.
    • Long-term follow-up of intraocular pressure and pressure-lowering medication in patients after ab-interno trabeculectomy with the Trabectome Avar M, Jordan JF, Neuburger M, Engesser D, Lübke J, Anton A, Wecker T Graefe's Archive for Clinical and Experimental Ophthalmology, 2019, DOI: 10.1007/s00417-019-04259-5
    • Long-term follow-up of intraocular pressure and pressure-lowering medication in patients following Excimer laser trabeculotomy Deubel C, Böhringer D, Anton A, Reinhard T, Lübke J Graefe's Archive for Clinical and Experimental Ophthalmology, 2020, DOI: 10.1007/s00417-020-05029-4
    • Ab Interno Trabeculectomy With the Trabectome as a Valuable Therapeutic Option for Failed Filtering Blebs Wecker T, Neuburger M, Bryniok L, Bruder K, Lübke J, Anton A, Jordan JF Journal of Glaucoma, 2016, DOI: 10.1097/IJG.0000000000000492
    • Trabeculectomy ab interno with the Trabectome® as a therapeutic option for uveitic secondary glaucoma Anton A, Heinzelmann S, Neß T, Lübke J, Neuburger M, Jordan JF, Wecker T Graefe's Archive for Clinical and Experimental Ophthalmology, 2015, DOI: 10.1007/s00417-015-3102-3
Principal Investigator

PD Dr. Jan Lübke, FEBO

jan.luebke@uniklinik-freiburg.de

Group Members

  • Julien Martin, MD
  • Dr. Cornelius Wiedenmann, MD
  • Luisa Goldmann, Lab Technician

Collaborators

  • IMTEK Freiburg 

Publications 

Funding 

  • Deutsche Forschungsgemeinschaft
  • Forschungsförderung der Forschungskommission, Universität Freiburg
  • Wilhelm-Seiter-Stiftung
  • Freunde der Universitäts-Augenklinik Freiburg e.V.