Föll, Melanie, Dr. rer. nat.
Institute of Surgical Pathology
University Medical Center Freiburg
melanie.foell@uniklinik-freiburg.de
Group Website: https://www.uniklinik-freiburg.de/pathologie/forschung/nachwuchsgruppe-maldi-imaging.html
Project title: Spatially resolved metabolomics and proteomics of solid tumors
My junior research group “MALDI imaging” investigates tumor tissue cohorts and organotypic tissue slice cultures by MALDI mass spectrometry imaging and complementary omics and imaging modalities. MALDI imaging derives hundreds of molecular distribution maps directly from thin tissue slices. We apply MALDI imaging of metabolites and peptides to investigate spatially resolved tumor biology and to derive spatio-molecular signatures with diagnostic and prognostic potential. Furthermore, we establish open-source analysis tools and workflows in the Galaxy platform and work towards standardization and reproducibility of MALDI imaging, which lays the foundation for future clinical applications.