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Institut für Medizinische Biometrie und Statistik (IMBI)

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Publikationen

2025

  • Rühle A, Weymann M, Behrens M, Olbrich J, Kut C, Marschner SN, Haderlein M, Fabian A, Senger C, Bakst BP, Kraft J, von der Grün J, Looman EL, Chen E, Domschikowski J, Altay-Langguth A, Kalinauskaite G, Lewitzki V, Bonomi M, Blakaj D, Jhawar SR, Baliga S, Elguindy AN, Ferentinos K, Zamboglou C, Müller JA, Leucht C, Dickstein DR, Schnellhardt S, Haehl E, Hambsch P, Kuhnt T, Seidel C, Belka C, et al. Predicting cisplatin tolerability in older adults with head and neck cancer - Insights for improved chemoradiation outcomes. Radiother Oncol. 2025 Mar;204:110697.
  • Pfaffenlehner M, Behrens M, Zöller D, Ungethüm K, Günther K, Rücker V, Reese JP, Heuschmann P, Kesselmeier M, Remo F, Scherag A, Binder H, Binder N, EVA4MII project. Methodological challenges using routine clinical care data for real-world evidence: a rapid review utilizing a systematic literature search and focus group discussion. BMC Med Res Methodol. 2025 Jan 14;25(1):8.
  • Hecht M, Blümle A, Binder H, Schumacher M, Binder N. Investigator-initiated versus industry-sponsored trials – visibility and relevance of randomized controlled trials in clinical practice guidelines (IMPACT). BMC Med Res Methodol. 2025 Mar 27;25(1):80.
  • Hackenberg M, Pfaffenlehner M, Behrens M, Pechmann A, Kirschner J, Binder H. Investigating a Domain Adaptation Approach for Integrating Different Measurement Instruments in a Longitudinal Clinical Registry. Biom J. 2025 Feb;67(1):e70023.
  • Farhadizadeh M, Weymann M, Blaß M, Kraus J, Gundler C, Walter S, Hempen N, Binder H, Binder N. Challenges and proposed solutions in modeling multimodal data: A systematic review [Internet]. arXiv; 2025. Available from: http://arxiv.org/abs/2505.06945

2024

  • Zöller D, Haverkamp C, Makoudjou A, Sofack G, Kiefer S, Gebele D, Pfaffenlehner M, Boeker M, Binder H, Karki K, Seidemann C, Schmeck B, Greulich T, Renz H, Schild S, Seuchter SA, Tibyampansha D, Buhl R, Rohde G, Trudzinski FC, Bals R, Janciauskiene S, Stolz D, Fähndrich S. Alpha-1-antitrypsin-deficiency is associated with lower cardiovascular risk: an approach based on federated learning. Respir Res. 2024 Jan 18;25(1):38.
  • Schwartz O, Vill K, Pfaffenlehner M, Behrens M, Weiß C, Johannsen J, Friese J, Hahn A, Ziegler A, Illsinger S, Smitka M, von Moers A, Kölbel H, Schreiber G, Kaiser N, Wilichowski E, Flotats-Bastardas M, Husain RA, Baumann M, Köhler C, Trollmann R, Schwerin-Nagel A, Eisenkölbl A, Schimmel M, Fleger M, Kauffmann B, Wiegand G, Baumgartner M, Rauscher C, Cirak S, Gläser D, Bernert G, Hagenacker T, Goldbach S, et al. Clinical Effectiveness of Newborn Screening for Spinal Muscular Atrophy: A Nonrandomized Controlled Trial. JAMA Pediatr. 2024 June 1;178(6):540–7.
  • Schönthaler M, Hempen N, Weymann M, Von Bargen MF, Glienke M, Elsässer A, Behrens M, Binder H, Binder N. A case is not a case is not a case - challenges and solutions in determining urolithiasis caseloads using the digital infrastructure of a clinical data warehouse [Internet]. Health Informatics; 2024 [cited 2025 Jan 13]. Available from: medrxiv.org/lookup/doi/10.1101/2024.09.13.24313333
  • Rühle A, Weymann M, Behrens M, Marschner S, Haderlein M, Fabian A, Senger C, Dickstein DR, Kraft J, von der Grün J, Chen E, Aquino-Michaels T, Domschikowski J, Bickel A, Altay-Langguth A, Kalinauskaite G, Lewitzki V, Bonomi M, Blakaj DM, Jhawar SR, Baliga S, Barve R, Ferentinos K, Zamboglou C, Schnellhardt S, Haehl E, Spohn SKB, Kuhnt T, Zöller D, Guckenberger M, Budach V, Belka C, Bakst R, Mayer A, et al. A Multicenter Evaluation of Different Chemotherapy Regimens in Older Adults With Head and Neck Squamous Cell Carcinoma Undergoing Definitive Chemoradiation. Int J Radiat Oncol Biol Phys. 2024 Apr 1;118(5):1282–93.
  • Pfefferle A, Binder N, Sauer J, Sofroniou M, Metzner G, Farin E, Voigt-Radloff S, Maun A, Salm C. Association between continuity of care and inappropriate prescribing in outpatient care in Germany: a cross-sectional analysis conducted as part of the LoChro trial. BMJ Open. 2024 July 22;14(7):e082245.
  • Möllenhoff K, Binder N, Dette H. Testing Similarity of Parametric Competing Risks Models for Identifying Potentially Similar Pathways in Healthcare. Stat Med. 2024 Dec 10;43(28):5316–30.
  • Behrens M, Farhadizadeh M, Rohde A, Rühle A, Nicolay NH, Binder H, Zöller D. Improving prediction models by incorporating external data with weights based on similarity [Internet]. arXiv; 2024. Available from: http://arxiv.org/abs/2405.07631

2023

  • Sprave T, Pfaffenlehner M, Stoian R, Christofi E, Rühle A, Zöller D, Fabian A, Fahrner H, Binder H, Schäfer H, Gkika E, Grosu AL, Heinemann F, Nicolay NH. App-Controlled Treatment Monitoring and Support for Patients With Head and Neck Cancer Undergoing Radiotherapy: Results From a Prospective Randomized Controlled Trial. J Med Internet Res. 2023 Oct 19;25:e46189.
  • Rühle A, Marschner S, Haderlein M, Fabian A, Weymann M, Behrens M, Senger C, Dickstein DR, Kraft J, von der Grün J, Chen E, Aquino-Michaels T, Domschikowski J, Bickel A, Altay-Langguth A, Kalinauskaite G, Lewitzki V, Ferentinos K, Zamboglou C, Schnellhardt S, Haehl E, Spohn SKB, Gkika E, Zöller D, Guckenberger M, Budach V, Belka C, Bakst R, Mayer A, Schmidberger H, Grosu AL, Balermpas P, Stromberger C, Nicolay NH. Evaluation of Concomitant Systemic Treatment in Older Adults With Head and Neck Squamous Cell Carcinoma Undergoing Definitive Radiotherapy. JAMA Netw Open. 2023 Feb 1;6(2):e230090.
  • Jørgensen CK, Olsen MH, Nielsen N, Lange T, Mbuagbaw L, Thabane L, Billot L, Binder N, Garattini S, Banzi R, Demotes J, Biagioli E, Rulli E, Bertolini G, Nattino G, Mathiesen O, Torri V, Gluud C, Jakobsen JC. Centre for Statistical and Methodological Excellence (CESAME): A Consortium Initiative for Improving Methodology in Randomised Clinical Trials. Health Serv Insights. 2023;16:11786329231166519.
  • Herz C, Frei L, Tran HTT, Claßen S, Spöttel J, Krell M, Hanschen FS, Arvandi M, Binder N, Schreiner M, Rohn S, Lamy E. A monocentric, randomized, double-blind, controlled crossover trial of nasturtium (Tropaeolum majus) on the lipid regulator prostaglandin E2. Front Nutr. 2023 Aug 3;10:1223158.

 

 

2022

  • Thriene K, Hansen SS, Binder N, Michels KB. Effects of Fermented Vegetable Consumption on Human Gut Microbiome Diversity—A Pilot Study. Fermentation. 2022 Mar 8;8(3):118.
  • Salm C, Sauer J, Binder N, Pfefferle A, Sofroniou M, Metzner G, Farin-Glattacker E, Voigt-Radloff S, Maun A. Over- and under-prescribing, and their association with functional disability in older patients at risk of further decline in Germany – a cross-sectional survey conducted as part of a randomised comparative effectiveness trial. BMC Geriatr. 2022 Dec;22(1):564.
  • Hackenberg M, Harms P, Pfaffenlehner M, Pechmann A, Kirschner J, Schmidt T, Binder H. Deep dynamic modeling with just two time points: Can we still allow for individual trajectories? Biom J. 2022 Dec;64(8):1426–45.
  • Binder N, Möllenhoff K, Sigle A, Dette H. Similarity of competing risks models with constant intensities in an application to clinical healthcare pathways involving prostate cancer surgery. Statistics in Medicine. 2022 Aug 30;41(19):3804–19.
  • Binder N, Franz J, Sigle A, Gratzke C, Miernik A. Lernen aus Kodierungsdaten – chirurgische Behandlung des benignen Prostatasyndroms: Big Data bei N40-Diagnose. Urologe. 2022 Feb;61(2):149–59.
  • Binder N, Dette H, Franz J, Zöller D, Suarez-Ibarrola R, Gratzke C, Binder H, Miernik A. Data Mining in Urology: Understanding Real-world Treatment Pathways for Lower Urinary Tract Systems via Exploration of Big Data. Eur Urol Focus. 2022 Apr 9;S2405-4569(22)00073-6.

2021

  • Werner SS, Binder N, Toews I, Schünemann HJ, Meerpohl JJ, Schwingshackl L. Use of GRADE in evidence syntheses published in high-impact-factor nutrition journals: a methodological survey. J Clin Epidemiol. 2021 Feb 12;
  • Sigle A, Jilg CA, Kuru TH, Binder N, Michaelis J, Grabbert M, Schultze-Seemann W, Miernik A, Gratzke C, Benndorf M, Suarez-Ibarrola R. Evaluation of the Ginsburg Scheme: Where Is Significant Prostate Cancer Missed? Cancers. 2021 May 20;13(10):2502.
  • Kohnert E, Kreutz C, Binder N, Hannibal L, Gorkiewicz G, Müller A, Storz MA, Huber R, Lederer AK. Changes in Gut Microbiota after a Four-Week Intervention with Vegan vs. Meat-Rich Diets in Healthy Participants: A Randomized Controlled Trial. Microorganisms. 2021 Mar 31;9(4):727.
  • Binder N, Lederer AK, Michels KB, Binder H. Assessing mediating effects of high-dimensional microbiome measurements in dietary intervention studies. Biom J. 2021 May 6

2020

  • Janda A, Eder K, Fressle R, Geweniger A, Diffloth N, Heeg M, Binder N, Sitaru AG, Rohr J, Henneke P, Hufnagel M, Elling R. Comprehensive infectious disease screening in a cohort of unaccompanied refugee minors in Germany from 2016 to 2017: A cross-sectional study. PLoS Med. 2020 Mar;17(3):e1003076.
  • Blümle A, Haag T, Balmford J, Rücker G, Schumacher M, Binder N. A multi-state model analysis of the time from ethical approval to publication of clinical research studies. PLoS One. 2020;15(3):e0230797.
  • Anderson AC, Al-Ahmad A, Schlueter N, Frese C, Hellwig E, Binder N. Influence of the long-term use of oral hygiene products containing stannous ions on the salivary microbiome – a randomized controlled trial. Sci Rep. 2020 Dec;10(1):9546.

2019

  • Michels KB, Binder N, Courant F, Franke AA, Osterhues A. Urinary excretion of sex steroid hormone metabolites after consumption of cow milk: a randomized crossover intervention trial. Am J Clin Nutr. 2019 Feb 1;109(2):402–10.
  • Binder N, Blümle A, Balmford J, Motschall E, Oeller P, Schumacher M. Cohort studies were found to be frequently biased by missing disease information due to death. J Clin Epidemiol. 2019 Jan;105:68–79.
  • Binder N, Balmford J, Schumacher M. A multi-state model based reanalysis of the Framingham Heart Study: Is dementia incidence really declining? Eur J Epidemiol. 2019 Nov;34(11):1075–83.

2018

  • Schlotz N, Odongo GA, Herz C, Waßmer H, Kühn C, Hanschen FS, Neugart S, Binder N, Ngwene B, Schreiner M, Rohn S, Lamy E. Are Raw Brassica Vegetables Healthier Than Cooked Ones? A Randomized, Controlled Crossover Intervention Trial on the Health-Promoting Potential of Ethiopian Kale. Nutrients. 2018 Nov 2;10(11).

2017

  • Toews I, Binder N, Wolff RF, Toprak G, von Elm E, Meerpohl JJ. Guidance in author instructions of hematology and oncology journals: A cross sectional and longitudinal study. PLoS One. 2017;12(4):e0176489.
  • Binder N, Manderscheid L, Schumacher M. The combined association of alcohol consumption with dementia risk is likely biased due to lacking account of death cases. Eur J Epidemiol. 2017 July;32(7):627–9.
  • Binder N, Herrnböck AS, Schumacher M. Estimating hazard ratios in cohort data with missing disease information due to death: Estimation in data with missing disease information due to death. Biom J. 2017 Mar;59(2):251–69.

2016

  • Binder N, Schumacher M. Letter to “Incidence of Dementia over Three Decades in the Framingham Heart Study.” N Engl J Med. 2016 July 7;375(1):92–3.

2015

  • Binder N, Schumacher M, Joly P. Re: “Incidence of Dementia Among Participants and Nonparticipants in a Longitudinal Study of Cognitive Aging.” American Journal of Epidemiology. 2015 Feb 15;181(4):291–2.

2014

  • Binder N, Schumacher M. Missing information caused by death leads to bias in relative risk estimates. J Clin Epidemiol. 2014 Oct;67(10):1111–20.
  • Binder N, Gerds TA, Andersen PK. Pseudo-observations for competing risks with covariate dependent censoring. Lifetime Data Anal. 2014 Apr;20(2):303–15.

2013

  • Schumacher M, Allignol A, Beyersmann J, Binder N, Wolkewitz M. Hospital-acquired infections--appropriate statistical treatment is urgently needed! Int J Epidemiol. 2013 Oct;42(5):1502–8.
  • Gathmann B, Goldacker S, Klima M, Belohradsky BH, Notheis G, Ehl S, Ritterbusch H, Baumann U, Meyer-Bahlburg A, Witte T, Schmidt R, Borte M, Borte S, Linde R, Schubert R, Bienemann K, Laws HJ, Dueckers G, Roesler J, Rothoeft T, Krüger R, Scharbatke EC, Masjosthusmann K, Wasmuth JC, Moser O, Kaiser P, Groß-Wieltsch U, Classen CF, Horneff G, Reiser V, Binder N, El-Helou SM, Klein C, Grimbacher B, et al. The German national registry for primary immunodeficiencies (PID): German registry for PID. Clin Exp Immunol. 2013 Aug;173(2):372–80.

2012

  • Rogacev KS, Cremers B, Zawada AM, Seiler S, Binder N, Ege P, Große-Dunker G, Heisel I, Hornof F, Jeken J, Rebling NM, Ulrich C, Scheller B, Böhm M, Fliser D, Heine GH. CD14++CD16+ Monocytes Independently Predict Cardiovascular Events. Journal of the American College of Cardiology. 2012 Oct;60(16):1512–20.
  • Bryceson YT, Pende D, Maul-Pavicic A, Gilmour KC, Ufheil H, Vraetz T, Chiang SC, Marcenaro S, Meazza R, Bondzio I, Walshe D, Janka G, Lehmberg K, Beutel K, zur Stadt U, Binder N, Arico M, Moretta L, Henter JI, Ehl S. A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes. Blood. 2012 Mar 22;119(12):2754–63.

2011

  • Wolkewitz M, Cooper B, Barnett AG, Binder N, Schumacher M. Treatment of hospital-acquired pneumonia. The Lancet Infectious Diseases. 2011 Oct;11(10):729.
  • Beyersmann J, Wolkewitz M, Allignol A, Grambauer N, Schumacher M. Application of multistate models in hospital epidemiology: Advances and challenges. Biom J. 2011 Mar;53(2):332–50.

2010

  • Grambauer N, Schumacher M, Beyersmann J. Proportional subdistribution hazards modeling offers a summary analysis, even if misspecified. Statist Med. 2010 Mar 30;29(7–8):875–84.
  • Grambauer N, Schumacher M, Dettenkofer M, Beyersmann J. Incidence Densities in a Competing Events Analysis. American Journal of Epidemiology. 2010 Nov 1;172(9):1077–84.