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Dr. Andreas B. Schmidt
Head of Hyperpolarization Group

Division of Medical Physics
Department of Radiology
University Medical Center Freiburg

PI of the German Cancer Consortium (DKTK)
German Cancer Research Center (DKFZ)

Killianstr. 5a
79106 Freiburg

Tel.: +49 761 270-93911

Short Bio:

Dr. Andreas B. Schmidt received his PhD in Physics from the University of Freiburg, Germany, where he developed a novel parahydrogen-based technique for liquid-state nuclear hyperpolarization without a polarizer. He holds a diploma in Physics from the same university and spent a year studying abroad at Universidad Complutense Madrid, Spain. He also holds a Master in Public Management from the University of Applied Sciences Kehl, Germany.

Dr. Schmidt is currently serving as the Head of the Hyperpolarization Group at the University Medical Center Freiburg, Germany, and as a Principal Investigator at the German Cancer Consortium partner site Freiburg. He has also held research fellowships at the University Hospital Schleswig-Holstein, Kiel, and at Wayne State University in Detroit. He is the overall coordinator of the HYPERBOLIC joint funding project within the German Cancer Consortium (DKTK), which links German research groups from Munich, Tübingen, Heidelberg, and Freiburg in their research activities on hyperpolarization. Since 2023, he is a Junior Fellow of the International Society for Magnetic Resonance in Medicine (ISMRM).

Dr. Schmidt’s research focuses on parahydrogen-based polarization methods, singlet states, hyperpolarization phenomena like radio amplification by stimulated emission of radiation (RASER), and chemical shift imaging.

Research (Group: Hyperpolarization)

Selected Publications:

  1. Schmidt, A. B.; Berner, S.; Schimpf, W.; Müller, C.; Lickert, T.; Schwaderlapp, N.; Knecht, S.; Skinner, J. G.; Dost, A.; Rovedo, P.; Hennig, J.; Elverfeldt, D. von; Hövener, J.-B. Liquid-State Carbon-13 Hyperpolarization Generated in an MRI System for Fast Imaging. Nat. Commun. 2017, 8, 14535. doi.org/10.1038/ncomms14535.
  2. Schmidt, A. B.; Berner, S.; Braig, M.; Zimmermann, M.; Hennig, J.; Elverfeldt, D. von; Hövener, J.-B. In Vivo 13C-MRI Using SAMBADENA. PLOS ONE 2018, 13 (7), e0200141. doi.org/10.1371/journal.pone.0200141.
  3. Mamone, S.; Schmidt, A. B.; Schwaderlapp, N.; Lange, T.; von Elverfeldt, D.; Hennig, J.; Glöggler, S. Localized Singlet-Filtered MRS in Vivo. NMR Biomed. 2020, e4400. doi.org/10.1002/nbm.4400.
  4. Schmidt, A. B.; Zimmermann, M.; Berner, S.; de Maissin, H.; Müller, C. A.; Ivantaev, V.; Hennig, J.; Elverfeldt, D. v; Hövener, J.-B. Quasi-Continuous Production of Highly Hyperpolarized Carbon-13 Contrast Agents Every 15 Seconds within an MRI System. Commun. Chem. 2022, 5 (1), 1–7. doi.org/10.1038/s42004-022-00634-2.
  5. Schmidt, A. B.; Bowers, C. R.; Buckenmaier, K.; Chekmenev, E. Y.; de Maissin, H.; Eills, J.; Ellermann, F.; Glöggler, S.; Gordon, J. W.; Knecht, S.; Koptyug, I. V.; Kuhn, J.; Pravdivtsev, A. N.; Reineri, F.; Theis, T.; Them, K.; Hövener, J.-B. Instrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization Techniques. Anal. Chem. 2022, 94 (1), 479–502. doi.org/10.1021/acs.analchem.1c04863.
  6. Schmidt, A. B.; de Maissin, H.; Adelabu, I.; Nantogma, S.; Ettedgui, J.; TomHon, P.; Goodson, B. M.; Theis, T.; Chekmenev, E. Y. Catalyst-Free Aqueous Hyperpolarized [1-13C]Pyruvate Obtained by Re-Dissolution Signal Amplification by Reversible Exchange. ACS Sens. 2022, 7 (11), 3430–3439. doi.org/10.1021/acssensors.2c01715.
  7. Chowdhury, R.; Mueller, C. A.; Smith, L.; Gong, F.; Papoutsaki, M.-V.; Rogers, H.; Syer, T.; Singh, S.; Brembilla, G.; Retter, A.; Bullock, M.; Caselton, L.; Mathew, M.; Dineen, E.; Parry, T.; Hennig, J.; von Elverfeldt, D.; Schmidt, A. B.; Hövener, J.-B.; Emberton, M.; Atkinson, D.; Bainbridge, A.; Gadian, D. G.; Punwani, S. Quantification of Prostate Cancer Metabolism Using 3D Multiecho BSSFP and Hyperpolarized [1-13C] Pyruvate: Metabolism Differs Between Tumors of the Same Gleason Grade. J. Magn. Reson. Imaging n/a (n/a). doi.org/10.1002/jmri.28467.
  8. Nelson, C.*; Schmidt, A. B*.; Adelabu, I.*; Nantogma, S.; Kiselev, V. G.; Abdurraheem, A.; de Maissin, H.; Lehmkuhl, S.; Appelt, S.; Theis, T.; Chekmenev, E. Y. Parahydrogen-Induced Carbon-13 Radiofrequency Amplification by Stimulated Emission of Radiation. Angew. Chem. Int. Ed. 2023, 62 (5), e202215678. doi.org/10.1002/anie.202215678.
  9. Schmidt, A. B.; Eills, J.; Dagys, L.; Gierse, M.; Keim, M.; Lucas, S.; Bock, M.; Schwartz, I.; Zaitsev, M.; Chekmenev, E. Y.; Knecht, S. Over 20% 13C Hyperpolarization for Pyruvate Using Deuteration and Rapid SLIC-SABRE in Mictrotesla Fields. 2023. doi.org/10.26434/chemrxiv-2023-ggvn4.
  10. Maissin, H. de; Groß, P.; Mohiuddin, O.; Weigt, M.; Nagel, L.; Herzog, M.; Wang, Z.; Willing, R.; Reichardt, W.; Pichotka, M.; Heß, L.; Reinheckel, T.; Jessen, H.; Zeiser, R.; Bock, M.; Elverfeldt, D. von; Zaitsev, M.; Korchak, S.; Glöggler, S.; Hövener, J.-B.; Chekmenev, E.; Schilling, F.; Knecht, S.; Schmidt, A. B. In Vivo Metabolic Imaging of [1-13C]Pyruvate-D3 Hyperpolarized By Reversible Exchange With Parahydrogen. 2023. doi.org/10.26434/chemrxiv-2023-9trxb.

PhD thesis:

"Liquid-State Nuclear Hyperpolarization Without a Polarizer – Synthesis Amid the Magnet Bore Allows a Dramatically Enhanced Nuclear Alignment" (25/02/2020, Department of Physics and Mathematics, University of Freiburg)

Diploma thesis:

"Nuclear hyperpolarization using twisted light beams at low magnetic fields" (03/11/2014, Department of Physics and Mathematics, University of Freiburg)

Research interests include

  • Nuclear Hyperpolarization
  • Singlet States and Singlet-Filtered (SiFi) Spectroscopy
  • Radio Amplification by Stimulated Emission of Radiation (RASER)
  • Low Field MRI and NMR
  • Metabolic and Molecular MRI