Institut für Neuropathologie

We investigate how organelle networks and cellular interactions regulate microglial function and brain homeostasis in health and neurodegeneration.

We seek to define intracellular mechanisms that govern cellular processes in the brain, with a particular focus on microglia, the immune cells of the brain. Our work centers on

• microglial organelle biology

• organelle-resolved multiomics

• and neuroimmune mechanisms in neurodegeneration.

To this end, we develop advanced human stem cell–derived systems and organelle-resolved multiomic profiling approaches. By isolating organelles using antibody-based capture, we detect subtle changes in protein, lipid, and metabolite composition at subcellular resolution, including shifts in their spatial distribution. Integrating these granular datasets with machine learning–based analysis and focused mechanistic interrogation, we aim to map cellular circuits that govern brain homeostasis and identify cellular vulnerabilities that drive disorders such as Alzheimer’s disease.

These insights guide the development of strategies to modulate dysfunctional neuroimmune and neuroglial interactions in brain diseases.

Our previous work established a method to isolate intact human microglial phagosomes. Multiomic profiling
revealed a highly dynamic compartment enriched in proteins linked to synapse regulation and neuro-
degenerative disease. We further identified the phagosome as a metabolic hub for de novo NAD⁺ 
biosynthesis in the brain. Together, these findings define the microglial phagosome as a central regulator
of CNS homeostasis and pathology.

(Wogram et al., Immunity, 2024).

Professional Education
• MD and Group Leader, Institute of Neuropathology - University Clinic Freiburg, Germany (since 2021)
• Postdoctoral fellow, Whitehead Institute for Biomedical Research, USA (2017-2021)
• Dissertation in Medicine (2017)
• Medical School, University of Heidelberg, Germany (2010-2017)

Honors & Awards
• Elite Programme for Postdoctoral Researchers, Baden-Württemberg Foundation (2025)
• Research Fellowship (Forschungsstipendium), German Research Foundation (DFG) (2017)
• MD Fellowship, Boehringer Ingelheim Fonds (2012)
• Scholarship, Studienstiftung des deutschen Volkes (German National Academic Foundation) (2011)

Members
• Lukas Faber, PhD Student
• Eva Paul, Cand. med.
• Anton Schoser, Cand. med.
• Lea Franz, Cand. med.

JOIN US!
• Master Thesis: Please send a CV (pdf) to emile.wogram@uniklinik-freiburg.de
• PhD: Please send a cover letter, CV, and contact information for two/three references (PDFs) to emile.wogram@uniklinik-freiburg.de

Publications

https://scholar.google.com/citations?user=bjsOl80AAAAJ&hl=en&oi=ao