Klinik für Anästhesiologie und Intensivmedizin

Zusatzqualifikationen

Internationales Zertifikat der Versuchstierkunde

Förderungen und Auszeichnungen

• 2005  Stipendium der Prof. Dr. Dr. Freifrau-von-Kleist Stiftung
• 2005  Auszeichung mit dem 'Young Investigators Award' auf dem 'RSV 2005 Symposium' in Oxford, UK
• 2006  Stipendium der Prof. Dr. Dr. Freifrau-von-Kleist Stiftung
• 2010  Travel Award der American Thoracic Society

Mitgliedschaften in Fachgesellschaften

American Thoracic Society

Wagner J, Strosing KM, Spassov SG, Lin Z, Engelstaedter H, Tacke S, Hoetzel A, Faller S. Sevoflurane posttreatment prevents oxidative and inflammatory injury in ventilator-induced lung injury. PLoS One. 2018 Feb 22;13(2):e0192896

Zimmermann KK, Spassov SG, Strosing KM, Ihle PM, Engelstaedter H, Hoetzel A, Faller S. Hydrogen Sulfide Exerts Anti-oxidative and Anti-inflammatory Effects in Acute Lung Injury. Inflammation. 2018 Feb;41(1):249-259

Spassov SG, Faller S, Hummel M, Helo K, Ihle A, Ryter SW, Strosing KM, Hoetzel A. Hydrogen Sulfide Confers Lung Protection During Mechanical Ventilation via Cyclooxygenase 2, 15-deoxy Δ12,14-Prostaglandin J2, and Peroxisome Proliferator-Activated Receptor Gamma. Crit Care Med. 2017 Aug;45(8):e849-e857

Faller S, Seiler R, Donus R, Engelstaedter H, Hoetzel A, Spassov SG. Pre- and posttreatment with hydrogen sulfide prevents ventilator-induced lung injury by limiting inflammation and oxidation. PLoS One. 2017 Apr 28;12(4):e0176649

Spassov SG, Donus R, Ihle PM, Engelstaedter H, Hoetzel A, Faller S. Hydrogen Sulfide Prevents Formation of Reactive Oxygen Species through PI3K/Akt Signaling and Limits Ventilator-Induced Lung Injury. Oxid Med Cell Longev. 2017;2017:3715037

Strosing KM, Faller S, Gyllenram V, Engelstaedter H, Buerkle H, Spassov S, Hoetzel A. Inhaled Anesthetics Exert Different Protective Properties in a Mouse Model of Ventilator-Induced Lung Injury. Anesth Analg. 2016 Jul;123(1):143-51

Spassov S, Pfeifer D, Strosing K, Ryter S, Hummel M, Faller S, Hoetzel A. Genetic targets of hydrogen sulfide in ventilator-induced lung injury--a microarray study. PLoS One. 2014 Jul 15;9(7):e102401

Faller S, Spassov SG, Zimmermann KK, Ryter SW, Buerkle H, Loop T, Schmidt R, Strosing KM, Hoetzel A. Hydrogen sulfide prevents hyperoxia-induced lung injury by downregulating reactive oxygen species formation and angiopoietin-2 release. Curr Pharm Des. 2013;19(15):2715-21

Faller S, Foeckler M, Strosing KM, Spassov S, Ryter SW, Buerkle H, Loop T, Schmidt R, Hoetzel A. Kinetic effects of carbon monoxide inhalation on tissue protection in ventilator-induced lung injury. Laboratory Investigation 2012; 92:999-1012.

Faller S, Strosing KM, Ryter SW, Buerkle H, Loop T, Schmidt R, Hoetzel A. Volatile Anesthetic Isoflurane Prevents Ventilator-Induced Lung Injury Via Phosphoinositide 3-Kinase/Akt Signaling in Mice. Anesth Analg. 2012; 114:747-56

Jessen B, Faller S, Krempl CD, Ehl S. Major histocompatibility complex-dependent cytotoxic T lymphocyte repertoire and functional avidity contribute to strain-specific disease susceptibility after murine respiratory syncytial virus infection. J Virol. 2011; 85:10135-43.

Faller S, Ryter SW, Choi AM, Loop T, Schmidt R, Hoetzel A. Inhaled hydrogen sulfide protects against ventilator-induced lung injury. Anesthesiology. 2010 113:104-15.

Hoetzel A, Schmidt R, Vallbracht S, Goebel U, Dolinay T, Kim HP, Ifedigbo E, Ryter SW, Choi AMK. Carbon monoxide prevents ventilator induced lung injury via caveolin-1. Crit Care Med 2009; 37:1708-15.

Hoetzel A, Dolinay T, Vallbracht S, Zhang Y, Kim HP, Ifedigbo E, Alber S, Kaynar AM, Schmidt R, Ryter SW, Choi AMK. Carbon monoxide protects against ventilator-induced lung injury via PPAR-gamma and inhibition of Egr-1. Am J Resp Crit Care Med 2008; 177:1223-32.

Vallbracht S., Jessen B., Mrusek S., Enders A., Collins P.L., Ehl S. and Krempl C.D. Influence of a single viral epitope on T cell response and disease after infection of mice with respiratory syncytial virus. J Immunol2007; 179:8264-73

Voges B., Vallbracht S., Zimmer G., Neubert W.J., Richter K., Hobeika E., Herrler G., Ehl S. Recombinant Sendai viurs induces T cell immunity against respiratory syncytial virus that is protective in the absence of antibodies. Cell Immunol 2007; 247:85-94.

Vallbracht S., Unsöld H., Ehl S. Functional impairment of cytotoxic T cells in the lung airways following respiratory virus infections. Eur J Immunol 2006; 36:1434-1442.

Mrusek S., Vallbracht S., Ehl S. The impact of spenectomy on antiviral T cell memory in mice. Int Immunol 2005; 17:27-33.

Ehl S., Bischoff R., Ostler T., Vallbracht S., Schulte-Monting J., Poltorak A., Freudenberg M. The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus. Eur J Immunol 2004; 34:1146-1153.

Rozman R., Exner C., Vallbracht S., Heldmaier G., Klingenspor M.: Effects of a high-energy diet and voluntary wheel running an body weight and energy balance in male Sprague-Dawley rats. Diet and Obesity Newsletter, No. 11 – June 2002

Übersichtsartikel

Faller S, Hoetzel A. Carbon Monoxide in Acute Lung Injury. Curr Pharm Biotechnol. 2012; 13:777-86

Buchbeiträge

Treude A., Vallbracht S., Ehrhardt N., Exner C. (2003): Mating, birth and early juvenile development in the Alpine marmots (Marmota marmota). In Adaptive strategies and diversity in marmots. Ramousse R., Alleiné D. & Le Berre M., Eds; International Marmot network, Lyon, 99-102

Wissenschaftliche Vorträge und Abstrakts

Faller S., Spassov S.G., Zimmermann K., Strosing K.M., Hoetzel A. (2012): Hydrogen Sulphide Mediates Protection In Hyperoxic Lung Injury Via Angiopoietin 2. American Thoracic Society, annual meeting 2012, San Fransisco, USA; Am. J. Respir. Crit. Care Med. 2012, in press

Spassov S., Faller S., Strosing K., Pfeifer D., Buerkle H., Hoetzel A. (2012): H2S Employs Suppressor Of Cytokine Signalling 3 In Protection Against VILI. American Thoracic Society, annual meeting 2012, San Francisco, USA; Am. J. Respir. Crit. Care Med. 2012, in press

Strosing K.M., Faller S., Spassov S.G., Hoetzel A.: Different protective properties of volatile anaesthetics in ventilator-induced lung injury. American Thoracic Society, annual meeting 2011, Denver, USA; Am. J. Respir. Crit. Care Med. 2011; 183: A1662.

Spassov S.G., Faller S., Strosing K., Zimmermann K., Hoetzel A. (2010): Protective effects of hydrogen sulphide in hyperoxic lung injury. American Thoracic Society, annual meeting 2011, Denver, USA; Am. J. Respir. Crit. Care Med. 2011; 183: A3983.

Faller S., Zimmermann K.K., Schmidt R., Hoetzel A. (2010): Inhaled hydrogen sulfide prevents lipopolysaccharide-induced lung injury. American Thoracic Society, annual meeting 2010, New Orleans, USA; Am. J. Respir. Crit. Care Med. 2010; 181: A6350.

Faller S., Strosing K.M., Schmidt R., Hoetzel A. (2010): The volatile anesthetic isoflurane prevents ventilator induced lung injury via the PI3K/Akt pathway. American Thoracic Society, annual meeting 2010, New Orleans, USA; Am. J. Respir. Crit. Care Med. 2010; 181: A4072.

Strosing K.M., Faller S., Hoetzel A. (2010): Isofluran vermindert den ventilatorinduzierten Lungenschaden über den Phosphatidylinositol-3-Kinase/Akt (PI3K/Akt)-Signaltransduktionsweg. Wissenschaftliche Arbeitstage der DGAI, 26.-27. Feb. 2010, Würzburg

Vallbracht S., Schmidt R, Hoetzel A. (2009): Suspended animation inducer hydrogen sulfide prevents ventilator associated lung injury. American Thoracic Society, annual meeting 2009, San Diego, USA; Am. J. Respir. Crit. Care Med. 2009; 179: A3823

Vallbracht S., Unsoeld H, Ehl S. (2006): Functional silencing of cytotoxic T cells in the lung airways following respiratory syncytial virus infections. 1st Joint Meeting of European National Societies of Immunology – 16th European Congress of Immunology, Paris

Vallbracht S., Voges B., Zimmer G., Herrler G., Ehl S. (2006): Ein rekombinantes Sendai Virus induziert balancierte Immunität gegen RSV im Atemwegstrakt von Mäusen. 102. Jahrestagung der Deutschen Gesellschaft für Kinder- und Jugendmedizin, Mainz

Vallbracht S., Voges B., Zimmer G., Herrler G., Ehl S. (2006): Recombinant Sendai Virus induces balanced immunity against RSV in mice. Jahrestreffen Arbeitskreis Vakzine, Freiburg

Vallbracht S., Enders A., Mrusek S. and Krempl C.D., Ehl S.(2005): A single mutation in the immunodominant CTL epitope of respiratory syncytial virus (RSV) changes the immunology of the viral infection. The Society of Virology, Study group "Immunobiology of Viral Infections", Schloß Zeilitzheim

Vallbracht S., Unsöld H., and Ehl S. (2005): Functional silencing of cytotoxic T cells in the bronchoalveolar space after respiratory virus infection. International Symposium on RSV, Oxford

Rozman R., Exner C., Vallbracht S., Heldmaier G., Klingenspor M. (2002): Effects of a high-energy diet and voluntary wheel running an body weight and energy balance in male Sprague-Dawley rats. Diet and Obesity Newsletter, No. 11

Ehrhardt N., Treude A., Vallbracht S., Exner C. (2001): Social interactions in alpine marmots (Marmota marmota) during mating season. 34. Jahrestagung: Physiologie und Pathologie der Fortpflanzung; S. 153