Studium und Ausbildung
| 1990 - 1995 | Studium der Biochemie und Mikrobiologie, University of Sofia, Bulgaria |
| 1995 | Master of Science (M.Sc.); Thema: "Microbiological monitoring of experimental purification equipment" |
| 2001 - 2006 | Postdoctoral fellow, Robert Koch Institut, Berlin, - Biomedical spectroscopy - Fourier-transform infrared (FT-IR) spectroscopy - Transmissible spongiform encephalopathie |
| 2006 | Promotion: "Investigation of scrapie associated prion protein PrP27-30 and strain differentiation of TSEs by FT-IR spectroscopy techniques" |
Wissenschaftliche Tätigkeit
| 1995 - 2000 | Wissenschaftlicher Mitarbeiter im Department of Virology, Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria - Virology - Cell culture and mouse model of Picornaviruses; Mouse model of Influenza virus - Experimental pharmacology - Immunology |
| 2007 - 2009 | Postdoctoral fellow, Department of Dermatology, University Medical Centre, Freiburg; AG Prof. L. Bruckner-Tuderman, - Inherited skin fragility disorders, - Folding and stability of collagen VII in DDEB, - Unfolded protein response, Autophagy, Apoptosis |
| 2009 - 2010 | Proteomics Core Facility, ZBSA, Freiburg - Establishment of Ultrasound assisted in-Gel protein digest, - Optimisation of methods for sample preparation. |
| seit 2010 | Wissenschaftlicher Angestellter, Anästhesiologische Universitätsklinik, Freiburg, AG Prof. Dr. A. Hötzel - Effekte von Hydrogensulfid auf den beatmungsassoziierten Lungenschaden ( in vivo und in vitro ) - Effekte von Hydrogensulfid auf den hyperoxieinduzierten Lungenschaden ( in vivo und in vitro ) |
Förderungen und Auszeichnungen
| 2011 | Travel Award der American Thoracic Society |
Wagner J, Strosing KM, Spassov SG, Lin Z, Engelstaedter H, Tacke S, Hoetzel A, Faller S. Sevoflurane posttreatment prevents oxidative and inflammatory injury in ventilator-induced lung injury. PLoS One. 2018 Feb 22;13(2):e0192896
Zimmermann KK, Spassov SG, Strosing KM, Ihle PM, Engelstaedter H, Hoetzel A, Faller S. Hydrogen Sulfide Exerts Anti-oxidative and Anti-inflammatory Effects in Acute Lung Injury. Inflammation. 2018 Feb;41(1):249-259
Spassov SG, Faller S, Hummel M, Helo K, Ihle A, Ryter SW, Strosing KM, Hoetzel A. Hydrogen Sulfide Confers Lung Protection During Mechanical Ventilation via Cyclooxygenase 2, 15-deoxy Δ12,14-Prostaglandin J2, and Peroxisome Proliferator-Activated Receptor Gamma. Crit Care Med. 2017 Aug;45(8):e849-e857
Faller S, Seiler R, Donus R, Engelstaedter H, Hoetzel A, Spassov SG. Pre- and posttreatment with hydrogen sulfide prevents ventilator-induced lung injury by limiting inflammation and oxidation. PLoS One. 2017 Apr 28;12(4):e0176649
Spassov SG, Donus R, Ihle PM, Engelstaedter H, Hoetzel A, Faller S. Hydrogen Sulfide Prevents Formation of Reactive Oxygen Species through PI3K/Akt Signaling and Limits Ventilator-Induced Lung Injury. Oxid Med Cell Longev. 2017;2017:3715037
Strosing KM, Faller S, Gyllenram V, Engelstaedter H, Buerkle H, Spassov S, Hoetzel A. Inhaled Anesthetics Exert Different Protective Properties in a Mouse Model of Ventilator-Induced Lung Injury. Anesth Analg. 2016 Jul;123(1):143-51
Spassov S, Pfeifer D, Strosing K, Ryter S, Hummel M, Faller S, Hoetzel A. Genetic targets of hydrogen sulfide in ventilator-induced lung injury--a microarray study. PLoS One. 2014 Jul 15;9(7):e102401
Faller S, Spassov SG, Zimmermann KK, Ryter SW, Buerkle H, Loop T, Schmidt R, Strosing KM, Hoetzel A. Hydrogen sulfide prevents hyperoxia-induced lung injury by downregulating reactive oxygen species formation and angiopoietin-2 release. Curr Pharm Des. 2013;19(15):2715-21
Faller S, Foeckler M, Strosing KM, Spassov S, Ryter SW, Buerkle H, Loop T, Schmidt R, Hoetzel A. Kinetic effects of carbon monoxide inhalation on tissue protection in ventilator-induced lung injury. Lab Invest. 2012; 92:999-1012.
Fritsch A*, Spassov S*, Elfert S*, Gache Y, Meneguzzi G, Bruckner-Tuderman L. Dominant negative effects of COL7A1 mutations can be rescued by controlled over-expression of normal collagen VII. J. Biol. Chem 2009;284:30248-56
Spassov S, Beekes M, Naumann D. Structural differences between TSEs strains investigated by FT-IR spectroscopy. Biochim Biophys Acta 2006; 1760:1138-49
Thomzig A*, Spassov S*, Friedrich M, Naumann D, Beekes M. Discriminating scrapie and BSE isolates by infrared spectroscopy of pathological prion protein. J. Biol. Chem. 2004; 279: 33847-54.