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Institut für Neuropathologie

Open Positions

PhD position Molecular Biology, Immunology, Biochemistry

We offer a PhD position within the Research Training Group 2606 ProPath located at the University Freiburg, Dept. Neuropathology, AG Molecular genetics (Knobeloch Lab).

The Research Training Group 2606 entitled Understanding Protease Functions in Cellular Pathways through Discovery and Analysis of Protease Substrates (ProtPath) is a German Research Foundation (DFG)-funded doctoral program for research concerning proteases, their substrates and their functions in biology and medicine. Biochemistry, cell biology, genetics, and proteomics are the key methodologies of our research endeavor.

Our work is focused on proteases counteracting protein modification by ubiquitin and ubiquitin-like modifiers such as ISG15 and SUMO. We generate conditional knockout mice for different Ubiquitin Specific Proteases (USPs) and use a wide range of molecular, immunological and cellular technologies to define physiological and molecular functions. A selection of recent publications is listed below (1-4).

The applicant should hold a master degree or equivalent in Biology, Molecular Medicine, Immunology, Biochemistry or a related field. A strong interest in molecular biology and willingness to work with mice is mandatory. Experience with ubiquitin or SUMO modification and/or mouse genetics is a plus. Beside creativity and strong motivation we expect good communication skills and the ability for teamwork.

References
1. Basters, A. et al. Structural basis of the specificity of USP18 toward ISG15. Nature structural & molecular biology, doi:10.1038/nsmb.3371 (2017).
2. Ketscher, L. et al. Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance. Proc Natl Acad Sci U S A 112, 1577-1582, doi:10.1073/pnas.1412881112 (2015).
3. Goldmann, T. et al. USP18 lack in microglia causes destructive interferonopathy of the mouse brain. The EMBO journal 34, 1612-1629, doi:10.15252/embj.201490791 (2015).
4.  Dufner, A. et al. The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells. Nature immunology 16, 950-960, doi:10.1038/ni.3230 (2015).

Bachelor/Master Thesis

Please feel free to contact us if you are interested in a Bachelor/Master thesis in our laboratory.

Principal Investigator

PD Dr. Klaus-Peter Knobeloch

University Clinic Freiburg

Institute of Neuropathology
Breisacher Straße 64
79106 Freiburg

Tel.: +49 761 270-51070
Fax: +49 761 270-50500
klaus-peter.knobeloch@uniklinik-freiburg.de