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Institut für Neuropathologie

Publications

Selected Publications

Inhibition of papain-like protease PLpro blocks 1 SARS-CoV-2 spread and promotes anti-viral immunity. Donghyuk Shin, Rukmini Mukherjee, Diana Grewe, Denisa Bojkova, Kheewoong Baek, Anshu Bhattacharya, Laura Schulz, Marek Widera, Ahmad Reza Mehdipour, Georg Tascher, Paul P. Geurink, Alexander Wilhelm, Gerbrand J. van der Heden van Noort, Huib Ovaa, Stefan Müller, Klaus-Peter Knobeloch, Krishnaraj Rajalingam, Brenda A. Schulman, Jindrich Cinatl, Gerhard Hummer, Sandra Ciesek, Ivan Dikic, Nature. 2020 Nov;587(7835):657-662.

 

Novel Hexb-based tools for studying microglia in the CNS. Masuda T, Amann L, Sankowski R, Staszewski O, Lenz M, D Errico P, Snaidero N, Costa Jordão MJ, Böttcher C, Kierdorf K, Jung S, Priller J, Misgeld T, Vlachos A, Luehmann MM, Knobeloch KP, Prinz M. Nat Immunol. 2020 Jul;21(7):802-815. doi: 10.1038/s41590-020-0707-4. Epub 2020 Jun 15. PMID: 32541832

 

Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming. Kespohl M, Bredow C, Klingel K, Voß M, Paeschke A, Zickler M, Poller W, Kaya Z, Eckstein J, Fechner H, Spranger J, Fähling M, Wirth EK, Radoshevich L, Thery F, Impens F, Berndt N, Knobeloch KP, Beling A. Sci Adv. 2020 Mar 11;6(11):eaay1109. doi: 10.1126/sciadv.aay1109. eCollection 2020 Mar. PMID:32195343

 

The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection. Zhang Y, Thery F, Wu NC, Luhmann EK, Dussurget O, Foecke M, Bredow C, Jiménez-Fernández D, Leandro K, Beling A, Knobeloch KP, Impens F, Cossart P, Radoshevich L. Nat Commun. 2019 Nov 26;10(1):5383. doi: 10.1038/s41467-019-13393-x. PMID:31772204

 

The probacterial effect of type I interferon signaling requires its own negative regulator USP18. Shaabani N, Honke N, Nguyen N, Huang Z, Arimoto KI, Lazar D, Loe TK, Lang KS, Prinz M, Knobeloch KP, Zhang DE, Teijaro JR.Sci Immunol. 2018 Sep 28;3(27). pii: eaau2125. doi: 10.1126/sciimmunol.aau2125. PMID:30266866

 

Post-translational control of T cell development by the ESCRT protein CHMP5. Adoro S, Park KH, Bettigole SE, Lis R, Shin HR, Seo H, Kim JH, Knobeloch KP, Shim JH, Glimcher LH. Nat Immunol. 2017 Jul;18(7):780-790. doi: 10.1038/ni.3764. Epub 2017 May 29. PMID:28553951

 

Structural basis of the specificity of USP18 toward ISG15. Basters A, Geurink PP, Röcker A, Witting KF, Tadayon R, Hess S, Semrau MS, Storici P, Ovaa H, Knobeloch KP*, Fritz G*. *Equal contribution Nat Struct Mol Biol. 2017 Mar;24(3):270-278. doi: 10.1038/nsmb.3371. Epub 2017 Feb 6. PMID:28165509

 

USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, Arbour N, Prat A, Majewski J, Lathrop M, Vidal SM, Gros P. Nat Immunol. 2017 Jan;18(1):54-63. doi: 10.1038/ni.3581. Epub 2016 Oct 10. PMID:27721430

 

ISG15 counteracts Listeria monocytogenes infection. Radoshevich L, Impens F, Ribet D, Quereda JJ, Nam Tham T, Nahori MA, Bierne H, Dussurget O, Pizarro-Cerdá J, Knobeloch KP, Cossart P. Elife. 2015 Aug 11;4. doi: 10.7554/eLife.06848. PMID:26259872

 

The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells. Dufner A, Kisser A, Niendorf S, Basters A, Reissig S, Schönle A, Aichem A, Kurz T, Schlosser A, Yablonski D, Groettrup M, Buch T, Waisman A, Schamel WW, Prinz M, Knobeloch KP. Nat Immunol. 2015 Sep;16(9):950-60. doi: 10.1038/ni.3230. Epub 2015 Jul 27. PMID:26214742

 

USP18 lack in microglia causes destructive interferonopathy of the mouse brain. Goldmann T, Zeller N, Raasch J, Kierdorf K, Frenzel K, Ketscher L, Basters A, Staszewski O, Brendecke SM, Spiess A, Tay TL, Kreutz C, Timmer J, Mancini GM, Blank T, Fritz G, Biber K, Lang R, Malo D, Merkler D, Heikenwälder M, Knobeloch KP*, Prinz M*. *Equal contribution EMBO J. 2015 Jun 12;34(12):1612-29. doi: 10.15252/embj.201490791. Epub 2015 Apr 20. PMID:25896511

 

Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance. Ketscher L, Hannß R, Morales DJ, Basters A, Guerra S, Goldmann T, Hausmann A, Prinz M, Naumann R, Pekosz A, Utermöhlen O, Lenschow DJ, Knobeloch KP. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1577-82. doi: 10.1073/pnas.1412881112. Epub 2015 Jan 20. PMID:25605921

 

Principal Investigator

PD Dr. Klaus-Peter Knobeloch

University Clinic Freiburg

Institute of Neuropathology
Breisacher Straße 64
79106 Freiburg

Tel.: +49 761 270-51070
Fax: +49 761 270-50500
klaus-peter.knobeloch@uniklinik-freiburg.de