Zu den Inhalten springen

Klinik für Anästhesiologie und Intensivmedizin

Prof. Dr. med. Alexander Hoetzel, M.A.

Publikationen

Originalarbeiten

Wagner J, Strosing KM, Spassov SG, Lin Z, Engelstaedter H, Tacke S, Hoetzel A, Faller S. Sevoflurane posttreatment prevents oxidative and inflammatory injury in ventilator-induced lung injury. PLoS One. 2018 Feb 22;13(2):e0192896

Zimmermann KK, Spassov SG, Strosing KM, Ihle PM, Engelstaedter H, Hoetzel A, Faller S. Hydrogen Sulfide Exerts Anti-oxidative and Anti-inflammatory Effects in Acute Lung Injury. Inflammation. 2018 Feb;41(1):249-259

Spassov SG, Faller S, Hummel M, Helo K, Ihle A, Ryter SW, Strosing KM, Hoetzel A. Hydrogen Sulfide Confers Lung Protection During Mechanical Ventilation via Cyclooxygenase 2, 15-deoxy Δ12,14-Prostaglandin J2, and Peroxisome Proliferator-Activated Receptor Gamma. Crit Care Med. 2017 Aug;45(8):e849-e857

Faller S, Seiler R, Donus R, Engelstaedter H, Hoetzel A, Spassov SG. Pre- and posttreatment with hydrogen sulfide prevents ventilator-induced lung injury by limiting inflammation and oxidation. PLoS One. 2017 Apr 28;12(4):e0176649

Spassov SG, Donus R, Ihle PM, Engelstaedter H, Hoetzel A, Faller S. Hydrogen Sulfide Prevents Formation of Reactive Oxygen Species through PI3K/Akt Signaling and Limits Ventilator-Induced Lung Injury. Oxid Med Cell Longev. 2017;2017:3715037

Strosing KM, Faller S, Gyllenram V, Engelstaedter H, Buerkle H, Spassov S, Hoetzel A. Inhaled Anesthetics Exert Different Protective Properties in a Mouse Model of Ventilator-Induced Lung Injury. Anesth Analg. 2016 Jul;123(1):143-51

Spassov S, Pfeifer D, Strosing K, Ryter S, Hummel M, Faller S, Hoetzel A. Genetic targets of hydrogen sulfide in ventilator-induced lung injury--a microarray study. PLoS One. 2014 Jul 15;9(7):e102401

Faller S, Spassov SG, Zimmermann KK, Ryter SW, Buerkle H, Loop T, Schmidt R, Strosing KM, Hoetzel A. Hydrogen sulfide prevents hyperoxia-induced lung injury by downregulating reactive oxygen species formation and angiopoietin-2 release. Curr Pharm Des. 2013;19(15):2715-21

Faller S, Foeckler M, Strosing KM, Spassov S, Ryter SW, Buerkle H, Loop T, Schmidt R, Hoetzel A. Kinetic effects of carbon monoxide inhalation on tissue protection in ventilator-induced lung injury. Lab Invest 2012; 92:999-1012

Faller S, Strosing KM, Ryter SW, Buerkle H, Loop T, Schmidt R, Hoetzel A. The volatile anesthetic isoflurane prevents ventilator-induced lung injury via phosphoinositide 3-kinase/Akt signaling. Anesth Analg 2012; 114:747-56

Schwer CI, Stoll P, Goebel U, Buerkle H, Hoetzel A, Schmidt R. Effects of hydrogen sulfide on rat pancreatic stellate cells. Pancreas 2012; 41:74-83

Schallner N, Schwemmers S, Schwer CI, Froehlich C, Stoll P, Humar M, Pahl HL, Hoetzel A, Loop T, Goebel U. p38-regulated induction of the heat shock response by carbon monoxide releasing molecule CORM-2 mediates cytoprotection in lung cells in vitro. Br J Pharmacol 2011; 670:58-66

Stoll P, Schwer CI, Goebel U, Buerkle H, Hoetzel A, Schmidt R. Hepatic steatosis prevents heme oxygenase-1 induction by isoflurane in the rat liver. World J Gastroenterol 2011; 17:4184-90

Schwer CI, Stoll P, Pietsch U, Stein P, Laqua J, Goebel U, Hoetzel A, Schmidt R. Up-regulation of heme oxygenase-1 by sevoflurane is not dependent on Kupffer cells and associates with ERK1/2 and AP-1 activation in the rat liver. Int J Biochem Cell Biol 2010; 42:1876-83.

Faller S, Ryter SW, Choi AM, Loop T, Schmidt R, Hoetzel A. Inhaled hydrogen sulfide protects against ventilator-induced lung injury. Anesthesiology 2010; 113:104-15.

Schwer CI, Mutschler M, Stoll P, Goebel U, Humar M, Hoetzel A, Schmidt R. Carbon monoxide releasing molecule-2 inhibits pancreatic stellate cell proliferation by activating p38 mitogen-activated protein kinase/heme oxygenase-1 signaling. Mol Pharmacol. 2010; 77:660-9  

Hoetzel A, Schmidt R, Vallbracht S, Goebel U, Dolinay T, Kim HP, Ifedigbo E, Ryter SW, Choi AMK, Carbon monoxide prevents ventilator induced lung injury via caveolin-1 Care Med 2009; 37:1708-15., Schmidt R, Vallbracht S, Goebel U, Dolinay T, Kim HP, Ifedigbo E, Ryter -1. Crit Care Med 2009; 37:1708-15.

Schwer CI, Guerrero AM, Humar M, Roesslein M, Goebel U, Stoll P, Geiger KK, Pannen BH, Hoetzel A, Schmidt R. Heme oxygenase-1 inhibits the proliferation of pancreatic stellate cells by repression of the ERK1/2 pathway. J Pharmacol Exp Ther 2008; 327:863-71

Hoetzel A, Dolinay T, Vallbracht S, Zhang Y, Kim HP, Ifedigbo E, Alber S, Kaynar AM, Schmidt R, Ryter SW, Choi AMK. Carbon monoxide protects against ventilator-induced lung injury via PPAR-and inhibition of Egr-1. Am J Resp Crit Care Med 2008; 177:1223-32.

Dolinay T, Wu W, Kaminski N, Ifedigbo E, Kaynar AM, Szilasi M, Watkins SC, Ryter SW, Hoetzel A, Choi AM. Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. PloS ONE 2008; 13:e1601.

Hoetzel A, Welle A, Schmidt R, Loop T, Humar M, Ryter SW, Geiger KK, Choi AM, Pannen BHJ. Nitric oxide-Deficiency Regulates Hepatic Heme Oxygenase–1. Nitric oxide 2008; 18:61-9.

Humar M, Dohrmann H, Stein P, Andriopoulos N, Goebel U, Heimrich B, Roesslein M, Schmidt R, Schwer C,Hoetzel A, Loop T, Pahl HL, Geiger KK, Pannen BH. Repression of T-cell function by thionamides is mediated by inhibition of the AP-1/NFAT pathway and is associated with a common structure. Mol Pharmacol 2007; 72:1647-54.

Humar M, Loop T, Schmidt R, Hoetzel A, Roesslein M, Andriopoulos N, Pahl HL, Geiger KK, Pannen BHJ. The mitogen-activated protein kinase p38 regulates activator protein 1 by direct phosphorylation of c-Jun. Int J Biochem Cell Biol 2007. 39:2278-88.

Schmidt R, Tritschler E, Hoetzel A, Loop T, Humar M, Halverscheid L, Geiger KK, Pannen BHJ.Heme oxygenase-1 induction by the clinically used anesthetic isoflurane protects rat livers from ischemia/reperfusion injury. Ann Surg 2007. 245:931-42.

Schmidt R, Baechle T, Hoetzel A, Loop T, Humar M, Roesslein M, Geiger KK, Pannen BH. Dihydralazine treatment limits liver injury after hemorrhagic shock in rats. Crit Care Med 2006 34:815-22.

Hoetzel A, Leitz D, Schmidt R, Tritschler E, Bauer I, Loop T, Humar M, Geiger KK, Pannen BH. Mechanism of hepatic heme oxygenase-1 induction by isoflurane. Anesthesiology 2006. 104:101-9.

Loop T, Dovi-Akue D, Frick M, Roesslein M, Egger L, Humar M, Hoetzel A, Schmidt R, Borner C, Pahl HL, Geiger KK, Pannen BH. Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitro.Anesthesiology 2005. 102:1147-57.

Schmidt R, Hoetzel A, Baechle T, Loop T, Humar M, Bauer M, Pahl HL, Geiger KK, Pannen BHJ. Isoflurane pretreatment lowers portal venous resistance by increasing hepatic heme oxygenase activity in the rat liver in vivo. J Hepatol 2004. 4:706-13.

Loop T, Bross T, Humar M, Hoetzel A, Schmidt R, Pahl HL, Geiger KK, Pannen BHJ. Dobutamine inhibits phorbol-myristate-acetate (PMA)-induced activation of nuclear factor-kappaB in human T-lymphocytes in vitro.Anesth Analg 2004. 99:1508-15.

Humar M, Andriopoulos N, Pischke SE, Loop T, Schmidt R, Hoetzel A, Roesslein M, Pahl HL, Geiger KK, Pannen BHJ. Inhibition of AP-1 by barbiturates is mediated by differential effects on MAP-kinases and the small G proteins Ras and Rac-1. J Pharmacol Exp Ther 2004. 311:1232-40.

Loop T, Scheiermann P, Doviakue D, Musshoff F, Humar M, Roesslein M, Hoetzel A, Schmidt R, Madea B, Geiger KK, Pahl HL, Pannen BHJ. Sevoflurane inhibits phorbol-myristate-acetate-induced activator protein-1 activation in human T lymphocytes in vitro: potential role of the p38-stress kinase pathway. Anesthesiology 2004. 101:710-21.

Humar M, Pischke SE, Loop T, Hoetzel A, Schmidt R, Klaas C, Pahl HL, Geiger KK, Pannen BHJ. Barbiturates directly inhibit the calmodulin/calcineurin complex: a novel mechanism of inhibition of nuclear factor of activated T cells. Mol Pharmacol 2004; 65:350-61.

Loop T; Humar M, Pischke S, Hoetzel A, Schmidt R, Pahl HL, Geiger KK, Pannen BHJ. Thiopental inhibits tumor necrosis factor -induced activation of nuclear factor B through suppression of IB kinase activity.Anesthesiology 2003; 99:360-7.

Hoetzel A, Geiger S, Loop T, Welle A, Schmidt R, Humar M, Pahl HL, Geiger KK, Pannen BHJ. Differential effects of volatile anesthetics on hepatic heme oxygenase-1 expression in the rat. Anesthesiology 2002; 97: 1318-21.

Loop T, Liu Z, Humar M, Hoetzel A, Benzing A, Pahl HL, Geiger KK, Pannen BHJ. Thiopental inhibits the activation of nuclear factor-kappaB. Anesthesiology 2001; 96: 1202-13.

Pannen BHJ, Schroll S, Loop T, Bauer M, Hoetzel A, Geiger KK. Hemorrhagic shock primes the hepatic portal circulation for the vasoconstrictive effects of endothelin-1. Am J Physiol Heart Circ Physiol. 2001; 281:H1075-84.

Hoetzel A, Vagts DA, Loop T, Humar M, Bauer M, Pahl HL, Geiger KK, Pannen BHJ. Effect of nitric oxide on shock-induced hepatic heme oxygenase-1 expression in the rat. Hepatology 2001; 33:925-37.

Masterman D, DeSalles A, Baloh RW, Frysinger R, Foti D, Behnke E, Cabatan Awang C, Hoetzel A, Intemann PM, Fairbanks L., Bronstein JM. Motor, cognitive, and behavioral performance following unilateral ventroposterior pallidotomy for Parkinson disease. Arch Neurol 1998; 55:1201-08.

 

Übersichtsarbeiten

Hoetzel A, Ryan H, Schmidt R. Anesthetic considerations for the patient with liver disease. Curr Opin Anaesthesiol 2012; 25:340-7

Schmidt R, Ryan H, Hoetzel A. Carbon monoxide - toxicity of low-dose application. Curr Pharm Biotechnol 2012; 13:837-50.

Faller S, Hoetzel A. Carbon monoxide in acute lung injury. Curr Pharm Biotechnol 2012;13:777-86

Hoetzel A, Schmidt R. Regulatory Role of Anesthetics on Heme Oxygenase-1. Curr Drug Targets 2010; 11:1495-503.  

Hoetzel A, Dolinay T, Schmidt R, Choi AMK, Ryter SW. Carbon monoxide in sepsis. Antioxid Redox Signal 2007; 9:2013-26

Ryter SW, Kim HP, Hoetzel A, Park JW, Nakahira K, Wang X, Choi AM. Mechanisms of cell death in oxidative stress. Antioxid Redox Signal 2007. 9: 49-89.

Hoetzel A, Schmidt R. Carbon monoxide - poison or potential therapeutic? [German]. Anaesthesist 2006. 55: 1068-79.

Hoetzel A and Geiger K. Stress proteins: basics and implications for anaesthesia & intensive care medicine [German]. Anästhesiologie & Intensivmedizin 2003. 44: 145-158.

 

Kasuistiken

Szibor-Kriesen U, Devide A, Hoetzel A, Vagts DA. Unstillbarer Schluckauf beim Patienten in der perioperativen Phase. Anasthesiol Intensivmed Notfallmed Schmerzther 2008; 43:674-676.

 

Buchbeiträge

Hoetzel A, Vasoaktive Medikamente, In: Benzing A, Pannen BHJ (Hrsg.): Praxishandbuch Anästhesie Spitta Verlag 2006.

 

Vorträge und Abstrakts

Symposium für Intensivtherapie und Intensivpflege 2012, Bremen. 
"Beatmung als Kreislauftherapie".

Anästhesiologische Fortbildung, Universität Tübingen 2012: 
"Lungenfunktionsdiagnostik".

American Thoracic Society, annual meeting 2012, San Francisco, USA: 
“Hydrogen sulphide mediates protection in hyperoxic lung injury via angiopoietin 2”.

American Thoracic Society, annual meeting 2012, San Francisco, USA: 
“H2S employs suppressor of cytokine signalling 3 in protection against VILI”.

6. Deutsch-Französischer Pharmazie Kongress 2011, Strasburg. 
"Pathophysiology of Sepsis".

1. Freiburger Airway-Workshop 2011, Freiburg. 
"Die fiberoptische Intubation"

 Süddeutsche Anästhesietage 2011, Mannheim. "Präoperative Evaluation der Lungenfunktion: Wo liegt die Relevanz?".

Süddeutsche Anästhesietage 2011, Mannheim. Vorsitz: 
"Nierenersatzverfahren".

Deutscher Anästhesie Congress 2011, Hamburg. 
"Bewusstlosigkeit nach Schlangenbiss".

American Thoracic Society, annual meeting 2011, Denver, USA: 
“Different protective properties of volatile anaesthetics in ventilator-induced lung injury”.

American Thoracic Society, annual meeting 2011, Denver, USA: 
“Protective effects of hydrogen sulphide in hyperoxic lung injury”.

Infektiologisches Symposium 2011, Freiburg. 
"Infektionen mit multiresistenten Erregern – rationale Therapieansätze".

Symposium für Intensivtherapie und Intensivpflege 2011, Bremen. 
"Beatmung als Kreislauftherapie".

Süddeutsche Anästhesietage 2010, Mannheim. Vorsitz: 
"Neue anti-infektive Strategien auf der Intensivstation".

American Thoracic Society, annual meeting 2010, New Orleans, USA: 
“The volatile anesthetic isoflurane prevents ventilator induced lung injury via the PI3K/Akt pathway”.

American Thoracic Society, annual meeting 2010, New Orleans, USA: 
“Inhaled hydrogen sulfide prevents lipopolysaccharide-induced lung injury”.

Wissenschaftliche Arbeitstage der DGAI 2010, Würzburg. Vorsitz: 
“Inflammation I“.

Wissenschaftliche Arbeitstage der DGAI 2010, Würzburg. 
“Isofluran vermindert den ventilator-induzierten Lungenschaden über den Phosphatidylinositol-3-Kinase/Akt (PI3K/Akt)-Signaltrans­duktions­weg“. 

American Thoracic Society, annual meeting 2009, San Diego, USA: 
"Suspended animation inducer hydrogen sulfide prevents ventilator associated lung injury".

Antrittsvorlesung, Universität Freiburg 2009: 
"Kohlenmonoxid: Gift oder potenzielles Therapeutikum".

Medizinische Fakultät der Universität Freiburg 2009: 
"Das therapeutische Potenzial der suspended animation".

American Thoracic Society, annual meeting 2008, Toronto, Canada: 
"Carbon monoxide prevents ventilator induced lung injury via caveolin-1".

The 5th International Congress on Heme Oxygenases 2007, Krakau, Polen: 
"Carbon monoxide exerts anti-inflammatory effects in ventilator induced lung injury via PPARy".

American Thoracic Society, annual meeting 2007, San Francisco, USA: 
"Anti-inflammatory effects of carbon monoxide in ventilator induced lung injury".

European Society of Anesthesiology, annual meeting 2007, München: 
"The protective role of carbon monoxide in ventilator induced lung injury", best abstract competition.

European Society of Anesthesiology, annual meeting 2005, Wien, Österreich: 
"Differential effects of nitric oxide synthases on heme oxygenase-1 in the normal and stress exposed liver". EJA 2005; 22: S164.

American society of anesthesiologists, annual meeting 2003, San Francisco, USA: 
"Mechanism of heme oxygenase-1 induction by volatile anesthetics in the liver"

American society of anesthesiologists, annual meeting 2003, San Francisco, USA: 
"Heme oxygenase-1 suppression by nitric oxide".

Heme oxygenase / CO Symposium 28. Sep. – 3. Okt. 2003, Uppsala, Schweden: 
"Regulation of heme oxygenase by volatile anesthetics in the liver"

Deutscher Anästhesie Kongress 9.-12. April 2003, München. 
"Induktion der hepatischen Hämoxygenase Typ 1 durch NO-Blockade in der Ratte".

Deutscher Anästhesie Kongress 9.-12. April 2003, München. 
"Mechanismus der Hämoxygenaseregulation durch Isoflurane in der Leber der Ratte."

Wissenschaftliche Arbeitstage der DGAI, 14.-15. Feb. 2003, Würzburg. 
"Mechanismus der Hämoxygenaseregulation durch Isoflurane in der Leber der Ratte".

2 nd Conference on heme oxygenase (HO/CO), 6.-9. Juni 2002, Catania, Italien. 
"Blockade of endogenous nitric oxide production induces hepatic heme oxygenase-1 expression".

Wissenschaftliche Arbeitstage der DGAI, 25.-26. Feb. 2002, Würzburg. 
"Induktion der Hämoxygenase-1 in der Leber der Ratte durch Hemmung der Stickstoffmonoxid-Synthase".

Shock Society, 3.-6. Juni 2000, Snowbird, USA. 
"Effect of nitric oxide on shock-induced hepatic heme oxygenase-1 expression in the rat". Shock suppl, A 78. 2001.

Kontakt

Klinik für Anästhesiologie
und Intensivmedizin
Universitätsklinikum Freiburg

Hugstetter Strasse 55
79106 Freiburg

Prof. Dr. med. Alexander Hötzel

Geschäftsführender Oberarzt

Facharzt für Anästhesiologie
Spezielle Intensivmedizin
Notfallmedizin
Palliativmedizin
M.A. Gesundheitsmanagement

Telefon   0761 270 - 23690 oder 23240
Telefax   0761 270 - 23960
E-Mail    
alexander.hoetzel@uniklinik-freiburg.de

Curriculum vitae

Publikationen