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Herausragende Publikationen

2022

SCIENCE TRANSLATIONAL MEDICINE

Human β-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling.


Rückert T, Andrieux G, Boerries M, Hanke-Müller K, Woessner NM, Doetsch S, Schell
C, Aumann K, Kolter J, Schmitt-Graeff A, Schiff M, Braun LM, Haring E, Kissel S,
Siranosian BA, Bhatt AS, Nordkild P, Wehkamp J, Jensen BAH, Minguet S, Duyster J,
Zeiser R, Köhler N.

Sci Transl Med. 2022 Dec 21;14(676):eabp9675. 

https://www.science.org/doi/10.1126/scitranslmed.abp9675?url_ver=Z39.88-2003&rfr_ HERAUSRAGENDE PUBLIKATION id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

Blood

Targeting MDM2 enhances anti-leukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation.

Ho JNHG, Schmidt D, Lowinus T, Ryoo J, Dopfer EP, Gonzalo Núñez N, Costa-Pereira S, Toffalori C, Punta M, Fetsch V, Wertheimer T, Rittmann MC, Braun LM, Follo M, Briere C, Vinnakota JM, Langenbach M, Koppers F, Shoumariyeh K, Engel H, Rückert T, Märklin M, Holzmayer S, Illert AL, Magon F, Andrieux G, Duquesne S, Pfeifer D, Staniek J, Rizzi M, Miething C, Köhler N, Duyster J, Menssen HD, Boerries M, Buescher JM, Cabezas-Wallscheid N, Blazar BR, Apostolova P, Vago L, Pearce EL, Becher B, Zeiser R.

Blood. 140, 1167-1181 (2022). DOI: 10.1182/blood.2022016082

 

Begleitet von diesem Editorial:

MDM2 inhibition augments GVL effect.

Bleakley M, Biernacki M.

Blood. 2022 Sep 8;140(10):1064-1065. DOI: 10.1182/blood.2022017724

Leukemia

Circulating tumor DNA in B-cell lymphoma: technical advances, clinical applications, and perspectives for translational research.

Eliza M. Lauer*, Jurik Mutter*, and Florian Scherer.

Leukemia. 2022. doi.org/10.1038/s41375-022-01618-w

Leukemia

Cell-free DNA for the detection of emerging treatment failure in relapsed/ refractory multiple myeloma.

Waldschmidt JM, Yee AJ, Vijaykumar T, Pinto RA, Frede J, Anand P, Bianchi G, Guo G, Potdar S, Seifer C, Nair MS, Kokkalis A, Kloeber JA, Shapiro S, Budano L, Mann M, Friedman R, Lipe B, Campagnaro E, O'Donnell EK, Zhang CZ, Laubach JP, Munshi NC, Richardson PG, Anderson KC, Raje NS, Knoechel B, Lohr JG.

Leukemia. 2022 Jan 13. doi: 10.1038/s41375-021-01492-y. Online ahead of print. PMID: 35027656

The Lancet Haematology
Lancet Haematol. 2022 Jan

Efficacy and safety of itacitinib versus placebo in combination with corticosteroids for initial treatment of acute graft-versus-host disease (GRAVITAS-301): a randomised, multicentre, double-blind, phase 3 trial

Zeiser R, Socié G, Schroeder MA, Abhyankar S, Vaz CP, Kwon M, Clausen J, Volodin L, Giebel S, Chacon MJ, Meyers G, Ghosh M, Deeren D, Sanz J, Morariu-Zamfir R, Arbushites M, Lakshminarayanan M, Barbour AM, Chen YB.

Lancet Haematol. 2022 Jan; 9(1):e14-e25. doi: 10.1016/S2352-3026(21)00367-7.

Nature Communications

Demethylating therapy increases anti-CD123 CAR T cell cytotoxicity against acute myeloid leukemia.

El Khawanky N, Hughes A, Yu W, Myburgh R, Matschulla T, Taromi S, Aumann K, Clarson J, Vinnakota JM, Shoumariyeh K, Miething C, Lopez AF, Brown MP, Duyster J, Hein L, Manz MG, Hughes TP, White DL, Yong ASM, Zeiser R.

Nature Commun. 2021 Nov 8;12(1):6436. doi: 10.1038/s41467-021-26683-0 | www.nature.com/articles/s41467-021-26683-0

Leukemia

The IL-3, IL-5, and GM-CSF Common Receptor Beta Chain Mediates Oncogenic Activity of FLT3-ITD-Positive AML.
Charlet, A.*, Kappenstein, M.*, Keye, P., Kläsener, K., Endres, C., Poggio, T., Gorantla, S. P., Kreutmair, S., Sänger, J., Illert, A. L., Miething, C., Reth, M., Duyster, J., Rummelt, C.*, von Bubnoff, N.*

* contributed equally

Leukemia 2021, 1–11  |  www.nature.com/articles/s41375-021-01462-4

 

Nature

Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine.
Oberhardt V, Luxenburger H, Kemming J, Schulien I, Ciminski K, Giese S, Csernalabics B, Lang-Meli J, Janowska I, Staniek J, Wild K, Basho K, Marinescu MS, Fuchs J, Topfstedt F, Janda A, Sogukpinar O, Hilger H, Stete K, Emmerich F, Bengsch B, Waller CF, Rieg S, Sagar, Boettler T, Zoldan K, Kochs G, Schwemmle M, Rizzi M, Thimme R, Neumann-Haefelin C, Hofmann M.
Nature. 2021 Sep;597(7875):268-273. doi: 10.1038/s41586-021-03841-4. Epub 2021 Jul 28. PMID: 34320609 | Mehr

Blood

Non-classical  manifestations of acute GVHD.
Zeiser R, Teshima T.

Blood. 2021 Sep 5:blood.2021012431. doi: 10.1182/blood.2021012431 | Mehr

New England Journal of Medicine

Ruxolitinib for Glucocorticoid-Refractory Chronic Graft-versus-Host Disease.

Zeiser R, Polverelli N, Ram R, Hashmi SK, Chakraverty R, Middeke JM, Musso M, Giebel S, Uzay A, Langmuir P, Hollaender N, Gowda M, Stefanelli T, Lee SJ, Teshima T, Locatelli F; REACH3 Investigators.

N Engl J Med. 2021 Jul 15;385(3):228-238. Mehr

Blood

CD44 loss of function sensitizes AML cells to the BCL-2 inhibitor venetoclax by decreasing CXCL12-driven survival cues.
Yu X, Munoz-Sagredo L, Streule K, Muschong P, Bayer E, Walter RJ, Gutjahr JC, Greil R, Concha ML, Müller-Tidow C, Hartmann TN, Orian-Rousseau V.

Blood. 2021 Jun 3:blood.2020006343. doi: 10.1182/blood.2020006343. Online ahead of print. Mehr

Blood

Invariant Natural Killer T Cell Subsets Have Diverse Graft-Versus-Host-Disease-Preventing and Anti-Tumor Effects
Kristina Maas-Bauer, Juliane K Lohmeyer, Toshihito Hirai, Teresa Lopes Ramos, Furqan Muhammad Fazal, Ulrike M Litzenburger, Kathryn E Yost, Jessica V Ribado, Neeraja Kambham, Arielle Wenokur, Po-Yu Lin, Maite Alvarez, Melissa Mavers, Jeanette Baker, Ami S Bhatt, Howard Chang, Federico Simonetta, Robert S Negrin.

Blood. 2021 May 25;blood.2021010887. doi: 10.1182/blood.2021010887. Online ahead of print. Mehr

Leukemia

Hypomethylating agents (HMA) for the treatment of acute myeloid leukemia and myelodysplastic syndromes: mechanisms of resistance and novel HMA-based therapies.

Stomper J, Rotondo JC, Greve G, Lübbert M.
Leukemia. 2021 May 6. doi: 10.1038/s41375-021-01218-0. Online ahead of print. Mehr

 

Journal of Clinical Oncology

Short Diagnosis-to-Treatment Interval Is Associated With Higher Circulating Tumor DNA Levels in Diffuse Large B-Cell Lymphoma

Alig S*, Macaulay CW*, Kurtz DM*, Dührsen U, Hüttmann A, Schmitz C, Jin MC, Sworder BJ, Garofalo A, Shahrokh Esfahani M, Nabet BY, Soo J, Scherer F, Craig AFM, Casasnovas O, Westin JR, Gaidano G, Rossi D, Roschewski M, Wilson WH, Meignan M, Diehn M, and Alizadeh AA.
J Clin Oncol. 2021 Apr 28

JCO2002573. doi: 10.1200/JCO.20.02573. PMID: 33909455 Mehr
 

Nature Communications

IL-33 expression in response to SARS-CoV-2 correlates with seropositivity in COVID-19 convalescent individuals

Stanczak MA#, Sanin DE#, Apostolova P#, Nerz G, Lampaki D, Hofmann M, Steinmann D, Krohn-Grimberghe M, Thimme R, Mittler G, Waller CF#*, Pearce EJ#*, Pearce EL#*.

# equal contribution | * co-corresponding
Nat Commun. 2021 Apr 9;12(1):2133. doi: 10.1038/s41467-021-22449-w. Mehr

Blood

Releasing the brake in CAR natural killer cells
Sophia Chen

Blood (2021) 137 (5): 579–581. Mehr

Science Translational Medicine
Science Translational Medicine

Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans.

Uhl FM, Chen S, O'Sullivan D, Edwards-Hicks J, Richter G, Haring E, Andrieux G, Halbach S, Apostolova P, Büscher J, Duquesne S, Melchinger W, Sauer B, Shoumariyeh K, Schmitt-Graeff A, Kreutz M, Lübbert M, Duyster J, Brummer T, Boerries M, Madl T, Blazar BR, Groß O, Pearce EL, Zeiser R.

Science Translational Med. 2020 Oct 28;12(567):eabb8969.


Blood | American Society of Hematology
Blood | American Society of Hematology

Glucagon like peptide-2 for Intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans.

Norona J, Apostolova P, Schmidt D, Ihlemann R, Reischmann N, Taylor G, Köhler N, de Heer J, Heeg S, Andrieux G, Siranosian BA, Schmitt-Graeff A, Pfeifer D, Catalano A, Frew I, Proietti M, Grimbacher B, Bulashevska A, Bhatt AS, Brummer T, Clauditz TS, Zabelina T, Kroeger N, Blazar BR, Boerries M, Ayuk F, Zeiser R.

Blood. 2020 Jun 15:blood.2020005957.

► doi.org/10.1182/blood.2020005957

Die Publikation wurde als Cover für das Journal "Blood" ausgewählt und von einem Editorial begleitet: ► https://ashpublications.org/blood/issue/136/12

Herzlichen Glückwunsch!


New England Journal of Medicine
New England Journal of Medicine

Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease.

Zeiser R, von Bubnoff N, Butler J, Mohty M, Niederwieser D, Or R, Szer J, Wagner EM, Zuckerman T, Mahuzier B, Xu J, Wilke C, Gandhi KK, Socié G, for the REACH2 Trial Group.

The New England Journal of Medicine Apr 22. ► doi: 10.1056/NEJMoa1917635 (2020).


Journal of Clinical Investigation

Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure.

Kreutmair S, Erlacher M, Andrieux G, Istvanffy R, Mueller-Rudorf A, Zwick M, Rückert T, Pantic M, Poggio T, Shoumariyeh K, Mueller TA, Kawaguchi H, Follo M, Klingeberg C, Wlodarski M, Baumann I, Pfeifer D, Kulinski M, Rudelius M, Lemeer S, Kuster B, Dierks C, Peschel C, Cabezas-Wallscheid N, Duque-Afonso J, Zeiser R, Cleary ML, Schindler D, Schmitt-Graeff A, Boerries M, Niemeyer CM, Oostendorp RA, Duyster J, Illert AL.

J Clin Invest. 2020 Apr 27. pii: 126215. ► doi: 10.1172/JCI126215.


Leukemia

TCL1 transgenic mice as a model for CD49d-high chronic lymphocytic leukemia
Szenes E, Härzschel A, Decker S, Tissino E, Pischeli J, Gutjahr JC, Kissel S, Pennisi S, Höpner JP, Egle A, Zaborsky N, Dierks C, Follo M, Chigaev A, Zucchetto A, Greil R, Gattei V, Hartmann TN
Leukemia. 2020 Feb 21. doi: 10.1038/s41375-020-0759-3. [Epub ahead of print]

► Artikel


New England Journal of Medicine
New England Journal of Medicine

Extracorporeal Photopheresis for Colitis Induced by Checkpoint-Inhibitor Therapy.

Apostolova P, Unger S, von Bubnoff D, Meiss F, Becher B, Zeiser R.
N Engl J Med. 2020 Jan 16;382(3):294-296.

► www.nejm.org/doi/full/10.1056/NEJMc1912274

 


Blood | American Society of Hematology
Blood | American Society of Hematology

CD49d promotes disease progression in chronic lymphocytic leukemia: new insights from CD49d bimodal expression

Tissino E, Pozzo F, Benedetti D, Caldana C, Bittolo T, Rossi FM, Bomben R, Nanni P, Chivilò H, Cattarossi I, Zaina E, Norris K, Polesel J, Gentile M, Tripepi G, Moia R, Santinelli E, Innocenti I, Olivieri J, D'Arena G, Laurenti L, Zaja F, Pozzato G, Chiarenza A, Di Raimondo F, Rossi D, Pepper C, Hartmann TN, Gaidano G, Del Poeta G, Gattei V, Zucchetto A.

Blood. 2020 Jan 31. pii: blood.2019003179. doi: 10.1182/blood.2019003179. [Epub ahead of print]
► ashpublications.org/blood/article-lookup/doi/10.1182/blood.2019003179


Journal of Clinical Investigation

Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia.

Mathew N, Vinnakota JM, Apostolova P, Erny D, Hamarsheh S, Andrieux G, Kim JS, Hanke K, Goldmann T, Chappell-Maor L, El-Khawanky N, Ihorst G, Schmidt D, Duyster J, Finke J, Blank T, Boerries M, Blazar BR, Jung S, Prinz M, Zeiser R.
J Clin Invest. 2019 Dec 17. pii: 130272. doi: 10.1172/JCI130272.