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Institut für Medizinische Mikrobiologie und Hygiene

PD Dr. Arnim Weber

Telefon Büro+49 761 203-5362
Telefon Labor+49 761 203-5363
Fax+49 761 203-6562
E-MailArnim.Weber@uniklinik-freiburg.de

CV

1992-1999Studium Diplom-Biologie, Universität Osnabrück
1999-2003 Promotion zum Dr. rer. nat., Universität Osnabrück
2004-2005 Wissenschaftlicher Mitarbeiter, LMU München (Prof. Dr. K. Jung, Mikrobiologie)
2005-2009 Wissenschaftlicher Mitarbeiter, TU München (Prof. Dr. med. G. Häcker, Med. Mikrobiologie und Hygiene)
2009-2014

 Wissenschaftlicher Mitarbeiter, Institut für Med. Mikrobiologie und Hygiene, Universitätsklinikum Freiburg (Prof. Dr. med. G. Häcker)

seit Dez. 2014 Arbeitsgruppenleiter am Institut für Med. Mikrobiologie und Hygiene, Universitätsklinikum Freiburg (Prof. Dr. med. G. Häcker)

Who is who?

NamePositionTelefonE-Mail
Dr. Arnim WeberAG-Leiter

203-5362

arnim.weber@uniklinik-freiburg.de
Manuel DoldBiol. Doktorand203-6546

manuel.dold@uniklinik-freiburg.de

Xiulin NgBiomed. Doktorandin203-6546xiulin.ng@uniklinik-freiburg.de

Originalarbeiten

Singh PK, Weber A, Häcker G. The established and the predicted roles of dynein light chain in the regulation of mitochondrial apoptosis.Cell Cycle. 2018 Jul 18:1-11. doi: 10.1080/15384101.2018.1464851. [Epub ahead of print] PMID:30019621

Mathew NR, Baumgartner F, Braun L, O'Sullivan D, Thomas S, Waterhouse M, Müller TA, Hanke K, Taromi S, Apostolova P, Illert AL, Melchinger W, Duquesne S, Schmitt-Graeff A, Osswald L, Yan KL, Weber A, Tugues S, Spath S, Pfeifer D, Follo M, Claus R, Lübbert M, Rummelt C, Bertz H, Wäsch R, Haag J, Schmidts A, Schultheiss M, Bettinger D, Thimme R, Ullrich E, Tanriver Y, Vuong GL, Arnold R, Hemmati P, Wolf D, Ditschkowski M, Jilg C, Wilhelm K, Leiber C, Gerull S, Halter J, Lengerke C, Pabst T, Schroeder T, Kobbe G, Rösler W, Doostkam S, Meckel S, Stabla K, Metzelder SK, Halbach S, Brummer T, Hu Z, Dengjel J, Hackanson B, Schmid C, Holtick U, Scheid C, Spyridonidis A, Stölzel F, Ordemann R, Müller LP, Sicre-de-Fontbrune F, Ihorst G, Kuball J, Ehlert JE, Feger D, Wagner EM, Cahn JY, Schnell J, Kuchenbauer F, Bunjes D, Chakraverty R, Richardson S, Gill S, Kröger N, Ayuk F, Vago L, Ciceri F, Müller AM, Kondo T, Teshima T, Klaeger S, Kuster B, Kim DDH, Weisdorf D, van der Velden W, Dörfel D, Bethge W, Hilgendorf I, Hochhaus A, Andrieux G, Börries M, Busch H, Magenau J, Reddy P, Labopin M, Antin JH, Henden AS, Hill GR, Kennedy GA, Bar M, Sarma A, McLornan D, Mufti G, Oran B, Rezvani K, Shah O, Negrin RS, Nagler A, Prinz M, Burchert A, Neubauer A, Beelen D, Mackensen A, von Bubnoff N, Herr W, Becher B, Socié G, Caligiuri MA, Ruggiero E, Bonini C, Häcker G, Duyster J, Finke J, Pearce E, Blazar BR, Zeiser R. Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. Nat Med. 2018 Apr 10;24(4):526. doi: 10.1038/nm0418-526c

Singh PK, Roukounakis A, Frank DO, Kirschnek S, Das KK, Neumann S, Madl J, Römer W, Zorzin C, Borner C, Haimovici A, Garcia-Saez A, Weber A, Häcker G. 2017. Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stbilize Mcl-1 and regulate apoptosis. Genes Dev. 2017 Sep 1;31(17):1754-1769.

Gentle IE, McHenry KT, Weber A, Metz A, Kretz O, Porter D, Häcker G. 2017. TIR-domian-containing adapter-inducing interferon-ß (TRIF) forms filamentous structures, whose pro-apoptotic signalling is terminated by autophagy. FEBSJ. 2017 Jul;284(13):1987-2003.

Weber A, Heinlein M, Dengjel J, Alber C, Singh PK, Häcker G. 2016. The deubiquitinase Usp27x stabalizes the BH3-only protein Bim and enhances apoptosis. EMBO Rep. 2016 May; 17(5):724-38.

Senft D, Weber A, Saathoff F, Berking C, Heppt MV, Kammerbauer C, Rothenfusser S, Kellner S, Kurgyis Z, Besch R, Häcker G. In non-transformed cells Bak activates upon loss of anti-apoptotic Bcl-XL and Mcl-1 but in the absence of active BH3-only proteins. Cell Death Dis. 2015 Nov 26;6:e1996.

Daniel O. Frank, Jörn Dengjel, Florian Wilfling, Vera Kozjak-Pavlovic, Georg Häcker, Arnim Weber. 2015. The Pro-Apoptotic BH3-Only Protein Bim Interacts with Components of the Translocase of the Outer Mitochondrial Membrane (TOM). PLoS ONE 04/2015; 10(4):e0123341.

Arnim Weber, David Ausländer, Georg Häcker. 2013. Mouse Noxa uses only the C-terminal BH3-domain to inactivate Mcl-1.Apoptosis 06/2013; 18(9).

F Wilfling, A Weber, S Potthoff, F-N Vögtle, C Meisinger, S A Paschen, G Häcker. 2012. BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax. Cell death and differentiation 02/2012; 19(8):1328-36.

Henry Zall, Arnim Weber, Robert Besch, Niko Zantl, Georg Häcker. 2010. Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1. Molecular Cancer 06/2010; 9:164.

A Weber, Z Kirejczyk, R Besch, S Potthoff, M Leverkus, G Häcker. 2009. Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells. Cell death and differentiation 12/2009; 17(6):942-51.

Diana Hippe, Arnim Weber, Liying Zhou, Donald C Chang, Georg Häcker, Carsten G K Lüder. 2009. Toxoplasma gondii infection confers resistance against Bim(S)-induced apoptosis by preventing the activation and mitochondrial targeting of pro-apoptotic Bax. Journal of Cell Science 10/2009; 122(Pt 19):3511-21.

Arnim Weber, Zofia Kirejczyk, Stephanie Potthoff, Christian Ploner, Georg Häcker. 2009. Endogenous Noxa Determines the Strong Proapoptotic Synergism of the BH3-Mimetic ABT-737 with Chemotherapeutic Agents in Human Melanoma Cells. Translational oncology 06/2009; 2(2):73-83.

Ralf Heermann, Arnim Weber, Bettina Mayer, Melanie Ott, Elisabeth Hauser, Günther Gabriel, Torsten Pirch, Kirsten Jung. 2008. The Universal Stress Protein UspC Scaffolds the KdpD/KdpE Signaling Cascade of Escherichia coli under Salt Stress. Journal of Molecular Biology 12/2008; 386(1):134-48.

Stefan A Paschen, Arnim Weber, Georg Häcker. 2007. Mitochondrial Protein Import: A Matter of Death? Cell cycle (Georgetown, Tex.) 11/2007; 6(20):2434-9.

Georg Häcker, Arnim Weber. 2007. BH3-only proteins trigger cytochrome c release, but how? Archives of Biochemistry and Biophysics 07/2007; 462(2):150-5.

Arnim Weber, Stefan A Paschen, Klaus Heger, Florian Wilfling, Tobias Frankenberg, Heike Bauerschmitt, Barbara M Seiffert, Susanne Kirschnek, Hermann Wagner, Georg Häcker. 2007. BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins. The Journal of Cell Biology 06/2007; 177(4):625-36.

Arnim Weber, Stephanie A Kögl, Kirsten Jung. 2006. Time-dependent proteome alterations under osmotic stress during aerobic and anaerobic growth in Escherichia coli. Journal of Bacteriology 11/2006; 188(20):7165-75.

Arnim Weber, Kirsten Jung. 2006. Biochemical properties of UspG, a universal stress protein of Escherichia coli. Biochemistry 03/2006; 45(6):1620-8.

Arnim Weber, Kirsten Jung. 2002. Profiling early osmostress-dependent gene expression in Escherichia coli using DNA macroarrays. Journal of Bacteriology 11/2002; 184(19):5502-7.

A Schlösser, A Weber, H Schrempf. 2001. Synthesis of the Streptomyces lividans maltodextrin ABC transporter depends on the presence of the regulator MalR. FEMS Microbiology Letters 04/2001; 196(1):77-83.

Institut für Medizinische Mikrobiologie und Hygiene

Hermann-Herder-Str. 11
D-79104 Freiburg

Ärztlicher Direktor
Prof. Dr. Georg Häcker
E-mail: georg.haecker@uniklinik-freiburg.de

Sekretariat
Kerstin Jost
Telefon: 0761 203-6532
Telefax: 0761 203-6651
E-mail: kerstin.jost@uniklinik-freiburg.de

Pforte
Jutta Schneeberger
Telefon: 0761 203-6510
Telefax: 0761 203-6562

Bestellung von Transportmedien
für H. pylori Resistenzbestimmungen

Telefon: 0761 203-6516
Telefax: 0761 203-6562

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