Zu den Inhalten springen

Institut für Medizinische Mikrobiologie und Hygiene

PD Dr. vet. Susanne Kirschnek

Telefon Büro+49 761 203-5362
Telefon Labor+49 761 203-5363
Fax+49 761 203-6651
E-Mailsusanne.kirschnek@uniklinik-freiburg.de

CV

10/1988-3/1995Studium der Veterinärmedizin, Universität Giessen
3/1995 Tierärztliches Staatsexamen, Approbation als Tierärztin
05/1995-07/1999 Doktorandin im Zentralen Tierlabor, Deutsches Krebsforschungszentrum, Heidelberg
5/2000Promotion zum Dr. med. vet., Tierärztliche Hochschule Hannover
09/1999-07/2000 Wissenschaftliche Mitarbeiterin, Institut für Physiologie, Universität Tübingen
07/2000-03/2002 Postdoctoral Research Associate, Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, USA
04/2002-10/2009 Wissenschaftliche Mitarbeiterin, Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, TU München (06/2004-03/2007 HWPII-Habilitationsstipendium)
3/2009Habilitation für das Fach Immunologie, Medizinische Fakultät, TU München
Seit 11/2009 Wissenschaftliche Mitarbeiterin, Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg

Who is who?

NamePositionTelefonE-Mail
PD Dr. vet. Susanne Kirschnek AG-Leiterin+49 761 203-5363susanne.kirschnek@uniklinik-freiburg.de
Tom ZortelBiol. Doktorand+49 761 203-5358tom.zortel@uniklinik-freiburg.de
Lioba KlaasMed. Doktorandin+49 761 203-5358lioba.klaas@uniklinik-freiburg.de
Juliane VierMTLA+49 761 203-5362juliane.vier@uniklinik-freiburg.de

1. Originalarbeiten

  • Gautam, S., S. Kirschnek, M. Wiesmeier, J. Vier, and G. Hacker. 2013. Roscovitine-induced Apoptosis in Neutrophils and Neutrophil Progenitors Is Regulated by the Bcl-2-Family Members Bim, Puma, Noxa and Mcl-1. PloS one 8:e79352.
  • Gautam, S., S. Kirschnek, I. E. Gentle, C. Kopiniok, P. Henneke, H. Hacker, L. Malleret, A. Belaaouaj, and G. Hacker. 2013. Survival and differentiation defects contribute to neutropenia in glucose-6-phosphatase-beta (G6PC3) deficiency in a model of mouse neutrophil granulocyte differentiation. Cell Death Differ 20:1068-1079.
  • Friesenhagen, J., D. Viemann, Y. Borgeling, M. Schmolke, C. Spiekermann, S. Kirschnek, S. Ludwig, and J. Roth. 2013. Highly pathogenic influenza viruses inhibit inflammatory response in monocytes via activation of rar-related orphan receptor RORalpha. Journal of innate immunity 5:505-518.
  • Kirschnek, S., J. Vier, S. Gautam, T. Frankenberg, S. Rangelova, P. Eitz-Ferrer, F. Grespi, E. Ottina, A. Villunger, H. Hacker, and G. Hacker. 2011. Molecular analysis of neutrophil spontaneous apoptosis reveals a strong role for the pro-apoptotic BH3-only protein Noxa. Cell Death Differ 18:1805-1814.
  • Eitz Ferrer, P., S. Potthoff, S. Kirschnek, G. Gasteiger, W. Kastenmuller, H. Ludwig, S. A. Paschen, A. Villunger, G. Sutter, I. Drexler, and G. Hacker. 2011. Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-beta-dependent induction of pro-apoptotic Noxa. PLoS pathogens 7:e1002083.
  • Lohmann, C., A. Muschaweckh, S. Kirschnek, L. Jennen, H. Wagner, and G. Hacker. 2009. Induction of tumor cell apoptosis or necrosis by conditional expression of cell death proteins: analysis of cell death pathways and in vitro immune stimulatory potential. J Immunol 182:4538-4546.
  • Koedel, U., T. Frankenberg, S. Kirschnek, B. Obermaier, H. Hacker, R. Paul, and G. Hacker. 2009. Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis. PLoS pathogens 5:e1000461.
  • Rangelova, S., S. Kirschnek, A. Strasser, and G. Hacker. 2008. FADD and the NF-kappaB family member Bcl-3 regulate complementary pathways to control T-cell survival and proliferation. Immunology 125:549-557.
  • Poeck, H., R. Besch, C. Maihoefer, M. Renn, D. Tormo, S. S. Morskaya, S. Kirschnek, E. Gaffal, J. Landsberg, J. Hellmuth, A. Schmidt, D. Anz, M. Bscheider, T. Schwerd, C. Berking, C. Bourquin, U. Kalinke, E. Kremmer, H. Kato, S. Akira, R. Meyers, G. Hacker, M. Neuenhahn, D. Busch, J. Ruland, S. Rothenfusser, M. Prinz, V. Hornung, S. Endres, T. Tuting, and G. Hartmann. 2008. 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nature medicine 14:1256-1263.
  • Frankenberg, T, S. Kirschnek, H. Hacker, and G. Hacker. 2008. Phagocytosis-induced apoptosis of macrophages is linked to uptake, killing and degradation of bacteria. European journal of immunology 38:204-215.
  • Zantl, N., G. Weirich, H. Zall, B. M. Seiffert, S. F. Fischer, S. Kirschnek, C. Hartmann, R. M. Fritsch, B. Gillissen, P. T. Daniel, and G. Hacker. 2007. Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance. Oncogene 26:7038-7048.
  • Weber, A., S. A. Paschen, K. Heger, F. Wilfling, T. Frankenberg, H. Bauerschmitt, B. M. Seiffert, S. Kirschnek, H. Wagner, and G. Hacker. 2007. BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins. J Cell Biol 177:625-636.
  • Bauer, A., S. Kirschnek, and G. Hacker. 2007. Inhibition of apoptosis can be accompanied by increased Bim levels in T lymphocytes and neutrophil granulocytes. Cell Death Differ 14:1714-1716.
  • Kirschnek, S., and E. Gulbins. 2006. Phospholipase A2 functions in Pseudomonas aeruginosa-induced apoptosis. Infect Immun 74:850-860.
  • Hacker, G., K. Suttner, H. Harada, and S. Kirschnek. 2006. TLR-dependent Bim phosphorylation in macrophages is mediated by ERK and is connected to proteasomal degradation of the protein. International immunology 18:1749-1757.
  • Hacker, G., S. Kirschnek, and S. F. Fischer. 2006. Apoptosis in infectious disease: how bacteria interfere with the apoptotic apparatus. Medical microbiology and immunology 195:11-19.
  • Kirschnek, S., S. Ying, S. F. Fischer, H. Hacker, A. Villunger, H. Hochrein, and G. Hacker. 2005. Phagocytosis-induced apoptosis in macrophages is mediated by up-regulation and activation of the Bcl-2 homology domain 3-only protein Bim. J Immunol 174:671-679.
  • Kirschnek, S., C. Adams, and E. Gulbins. 2005. Annexin II is a novel receptor for Pseudomonas aeruginosa. Biochem Biophys Res Commun 327:900-906.
  • Fischer, S. F., M. Rehm, A. Bauer, F. Hofling, S. Kirschnek, M. Rutz, S. Bauer, H. Wagner, and G. Hacker. 2005. Toll-like receptor 9 signaling can sensitize fibroblasts for apoptosis. Immunology letters 97:115-122.
  • Kirschnek, S., J. Scheffel, U. Heinzmann, and G. Hacker. 2004. Necrosis-like cell death induced by bacteria in mouse macrophages. European journal of immunology 34:1461-1471.
  • Fischer, S. F., J. Vier, S. Kirschnek, A. Klos, S. Hess, S. Ying, and G. Hacker. 2004. Chlamydia inhibit host cell apoptosis by degradation of proapoptotic BH3-only proteins. The Journal of experimental medicine 200:905-916.
  • Kirschnek, S., F. Paris, M. Weller, H. Grassme, K. Ferlinz, A. Riehle, Z. Fuks, R. Kolesnick, and E. Gulbins. 2000. CD95-mediated apoptosis in vivo involves acid sphingomyelinase. J Biol Chem 275:27316-27323.
  • Grassme, H., S. Kirschnek, J. Riethmueller, A. Riehle, G. von Kurthy, F. Lang, M. Weller, and E. Gulbins. 2000. CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa. Science 290:527-530.
  • Bootz, F., S. Kirschnek, W. Nicklas, S. K. Wyss, and F. R. Homberger. 1998. Detection of Pasteurellaceae in rodents by polymerase chain reaction analysis. Laboratory animal science 48:542-546.    

Institut für Medizinische Mikrobiologie und Hygiene

Hermann-Herder-Str. 11
D-79104 Freiburg

Ärztlicher Direktor
Prof. Dr. Georg Häcker
E-mail: georg.haecker@uniklinik-freiburg.de

Sekretariat
Kerstin Jost
Telefon: 0761 203-6532
Telefax: 0761 203-6651
E-mail: kerstin.jost@uniklinik-freiburg.de

Pforte
Jutta Schneeberger
Telefon: 0761 203-6510
Telefax: 0761 203-6562

Bestellung von Transportmedien
für H. pylori Resistenzbestimmungen

Telefon: 0761 203-6516
Telefax: 0761 203-6562

Lageplan