Eva Rog-Zielinska, PhD
Head of 4D Imaging, Emmy Noether Fellow
Research Interests:
- Nano-to-micro scale investigation of the impact of mechanical activity on cardiac T-tubular system
- Mechanisms of mechanosensing
- Properties of myocardial infarction scars
Brief CV:
Eva obtained her Biotechnology Master’s degree from the Nicolaus Copernicus University in Torun, Poland. She was then awarded a 4-year British Heart Foundation PhD studentship at the University of Edinburgh in 2008, during which time she investigated late gestation development of the heart. Since 2013 she has been working with Professor Peter Kohl at Imperial College London and IEKM at Freiburg. In 2015 Eva has been awarded a 3-year BHF Immediate Post-doctoral Basic Research Fellowship. She maintains close collaborations with University of Colorado Boulder, University of Bristol, and EMBL Heidelberg. Since 2017 she heads the 4D Imaging section at the IEKM in Freiburg, since August 2018 as an Emmy Noether Fellow.
Selected Publications:
- Rog-Zielinska EA, Grune J, Kessler T, Lother A, Kohl P. Interstitial cells and arrhythmia. Am J Physiol Cell Physiol 2026/330:C943-C953
- Orós-Rodrigo S, Fu J, Greiner J, Madl J […] Zgierski-Johnston CM [...] Kohl P, Rog-Zielinska EA. Cardiomyocyte mechanical activity counteracts intraluminal calcium depletion in the transverse-axial tubular system during fast electrical stimulation. bioRxiv 2026
- Greiner J, Sonak F, Jones WD, Madl J […] Kohl P, Rog-Zielinska EA. Architecture of the cardiac transverse-axial tubular system across different mammalian species. bioRxiv 2026
- Greiner J, Frangiamore F, Sonak F, Madl J, Seidel T, Kohl P, Rog-Zielinska EA. A deep learning-enabled toolkit for the 3D segmentation of ventricular cardiomyocytes. J Physiol 2025/in press
- Giardini F […] Rog-Zielinska EA […] Kohl P […] Zgierski-Johnston CM, Sacconi L. Correlative imaging integrates electrophysiology with three-dimensional murine heart reconstruction to reveal electrical coupling between cell types. Nat Cardiovasc Res 2025/4:1466-1486
- Pronto JRD […] Rog-Zielinska EA […] Voigt N. Impaired atrial mitochondrial calcium handling in patients with atrial fibrillation. Circ Res 2025/137:1333-1352
- Fu J, Cameron BA […] Ravens U, Kohl P, Rog-Zielinska EA […] Peyronnet R. Stretch-induced increase in Ca2+-spark rate in rabbit atrial cardiomyocytes requires TRPA1 and intact microtubule network. J Am Heart Assoc 2025/14:e040495
- Greiner J […] Zgierski-Johnston CM, Peyronnet R, Kohl P, Sacconi L, Rog-Zielinska EA. Different effects of cardiomyocyte contractile activity on transverse and axial tubular system luminal content dynamics. J Mol Cell Cardiol 2024/197:125-135
- Paulke NJ […] Rog-Zielinska EA, Lehnart SE, Brandenburg S. Dysferlin enables tubular membrane proliferation in cardiac hypertrophy. Circ Res 2024/135:554-574
- Fürniss HE, Wülfers EM, Iaconniani P, Ravens U [...] Kohl P, Rog-Zielinska EA*, Peyronnet R*. Disease severity, arrhythmogenesis, and fibrosis are related to longer action potentials in tetralogy of Fallot. Clin Res Cardiol 2023/113:716–727
- Kohl P, Greiner, J, Rog-Zielinska EA. Electron microscopy of cardiac 3D nanodynamics: form, function, future. Nat Rev Cardiol 2022/19(9):607-619
- Rog-Zielinska EA , Moss R, Kaltenbacher W, Greiner J [...] Seemann G, Kohl P, Cannell MB. Nano-scale morphology of cardiomyocyte t-tubule/sarcoplasmic reticulum junctions revealed by ultra-rapid high-pressure freezing and electron tomography. J Mol Cell Cardiol 2021/153:86-92
- Rog-Zielinska EA [...] Peyronnet R, Zgierski-Johnston, Greiner J, Madl J [...] Kohl P. Beat-by-beat cardiomyocyte T-tubule deformation drives tubular content exchange. Circ Res 2020/128(2):203-215
- MacDonald EA, Madl J, Greiner J […] Rog-Zielinska EA*, Quinn TA*. Sinoatrial node structure, mechanics, electrophysiology and the chronotropic response to stretch in rabbit and mouse. Front Physiol 2020/11:908 (*joint authorship)
- Rog-Zielinska EA, O'Toole ET, Hoenger A, Kohl P. Mitochondrial Deformation During the Cardiac Mechanical Cycle. Anat Rec 2018/302:146-152
- Kong CHT*, Rog-Zielinska EA*, Kohl P, Orchard CH, Cannell MB. Solute movement in the t-tubule system of rabbit and mouse cardiomyocytes. PNAS USA 2018/115:E7073-E7080 (*joint authors)
- Scardigli M [...] Rog-Zielinska EA, Kohl P [...] Sacconi L. Quantitative assessment of passive electrical properties of the cardiac T-tubular system by FRAP microscopy. PNAS USA 2017/114:5737-5742
- Brandenburg S [...] Rog-Zielinska EA [...] Kohl P [...] Lehnart SE. Axial tubule junctions control rapid calcium signaling in atria. J Clin Invest 2016/126:3999-4015
- Quinn TA, Camelliti P, Rog-Zielinska EA [....] Kohl P. Electrotonic coupling of excitable and non-excitable cells in the heart revealed by optogenetics. PNAS USA 2016/113:14852-14857
- Rog-Zielinska EA, Johnston CM [...] Kohl P. Electron tomography of rabbit cardiomyocyte three-dimensional ultrastructure. Prog Biophys Mol Biol 2016/121:77-84
- Rog-Zielinska EA, Norris RA, Kohl P, Markwald R. The Living Scar - Cardiac Fibroblasts and the Injured Heart. Trends Mol Med 2016/22:99-114
All Publications:
Contact
eva.rog-zielinska@uniklinik-freiburg.de
+49 (0)761 270 63954