Remi Peyronnet, PhD
Head of Mechanobiology
Contact
remi.peyronnet@uniklinik-freiburg.de
+49 (0)761 270 63953
Research Interests:
- Identification and characterisation of cardiac cell mechano-sensors
- Mechano-stimulation of cells and tissues
- Characterisation of the adaptation of biological processes to mechanical forces
- Characterisation of cell and tissue mechanical properties in different mechanical environment
Brief CV:
Rémi studied physiology at the Limoges Faculty of Science and Technology (2000-2004), and then he completed his Master and PhD at the Orsay Faculty of Science (Paris XI) in 2005 and 2009, respectively. In 2010, he joined Dr Eric Honoré at the Institute of Molecular and Cellular Pharmacology (IPMC), Sophia-Antipolis, with the support of an AFM (Association Française contre les Myopathies) Postdoctoral Research Fellowship to investigate the role and relevance of mechano-transduction mechanisms in Autosomal Dominant Polycystic Kidney Disease. In 2013, he obtained an Imperial College’s Junior Research Fellowship and joined Prof. Peter Kohl’s group to identify mechano-sensors in heart valves. Since 2016 Rémi Peyronnet heads the Cell Biophysics section at the IEKM in Freiburg.
Selected Publications:
- Fu J, Cameron BA, Schönleitner P, Schiatti T, Kuiper M, Kittel AS, Simon-Chica A, Madl J, Kreutz C, Filgueiras-Rama D, Schotten U, Römer W, Ravens U, Kohl P, Rog-Zielinska EA, Antoons G, Peyronnet R. Stretch-Induced Increase in Ca2+-Spark Rate in Rabbit Atrial Cardiomyocytes Requires TRPA1 and Intact Microtubule Network. J Am Heart Assoc 2025/14:e040495
- Cameron BA, Baumeister PA, Lawen T, Rafferty SA, Taeb B, Stoyek MR, Greiner J, Uzelac I, Fenton FH, Peyronnet R, Kohl P, Quinn TA. Disturbed Repolarization-Relaxation Coupling During Acute Myocardial Ischemia Permits Systolic Mechano-Arrhythmogenesis. Circ Res. 2025/137:363
- Meral D, Mamazhakypov A, Juncker K, Calderón-Fernández M, Peyronnet R, Zgierski-Johnston C, Preissl S, Lother A. Cell Type-Resolved Transcriptome of Aldosterone-Induced Atrial Myopathy and Arrhythmia. Hypertension 2025/82:e105
- Simon-Chica A, Klesen A, Emig R, Chan A, Greiner J, Grün D, Lother A, Hilgendorf I, Rog-Zielinska EA, Ravens U, Kohl P, Schneider-Warme F, Peyronnet R. Piezo1 stretch-activated channel activity differs between murine bone marrow-derived and cardiac tissue-resident macrophages. J Physiol. 2024/602:4437
- Fürniss HE, Wülfers EM, Iaconianni P, Ravens U, Kroll J, Stiller B, Kohl P, Rog-Zielinska EA, Peyronnet R. Disease severity, arrhythmogenesis, and fibrosis are related to longer action potentials in tetralogy of Fallot. Clin Res Cardiol. 2024/113:716
- Darkow E, Yusuf D, Rajamani S, Backofen R, Kohl P, Ravens U, Peyronnet R. Meta-Analysis of Mechano-Sensitive Ion Channels in Human Hearts: Chamber- and Disease-Preferential mRNA Expression. Int J Mol Sci. 2023/24:10961
- Khokhlova A, Solovyova O, Kohl P, Peyronnet R. Single cardiomyocytes from papillary muscles show lower preload-dependent activation of force compared to cardiomyocytes from the left ventricular free wall. J Mol Cell Cardiol. 2022/166:127
- Jakob D, Klesen A, Allegrini B, Darkow E, Aria D, Emig R, Chica AS, Rog-Zielinska EA, Guth T, Beyersdorf F, Kari FA, Proksch S, Hatem SN, Karck M, Künzel SR, Guizouarn H, Schmidt C, Kohl P, Ravens U, Peyronnet R. Piezo1 and BKCa channels in human atrial fibroblasts: Interplay and remodelling in atrial fibrillation. J Mol Cell Cardiol. 2021/158:49
- Emig R, Knodt W, Krussig MJ, Zgierski-Johnston CM, Gorka O, Groß O, Kohl P, Ravens U, Peyronnet R. Piezo1 Channels Contribute to the Regulation of Human Atrial Fibroblast Mechanical Properties and Matrix Stiffness Sensing. Cells. 2021/10:663
- Darkow E, Rog-Zielinska EA, Madl J [...] Kohl P, Ravens U, Römer W, Peyronnet R. The Lectin LecA Sensitizes the Human Stretch-Activated Channel TREK-1 but Not Piezo1 and Binds Selectively to Cardiac Non-myocytes. Front Physiol 2020/11:457
- Emig R, Zgierski-Johnston CM, Beyersdorf F, Rylski B, Ravens U, Weber W, Kohl P, Hörner M, Peyronnet R. Human Atrial Fibroblast Adaptation to Heterogeneities in Substrate Stiffness. Front Physiol 2020/10:1526
- Odening KE, Bodi I [...] Perez-Feliz S, Fürniss H, Mettke L, Michaelides K [...] Peyronnet R [...] Bode C, Jolivet G, Brunner M. Transgenic short-QT syndrome 1 rabbits mimic the human disease phenotype with QT/APD shortening in the atria and ventricles and increased VT/VF inducibility. Eur Heart J 2019/40:842-853
- Peyronnet R, Bollensdorff C, Capel RA, Rog-Zielinska EA, Woods CE, Charo DN, Lookin O, Fajardo G, Ho M, Quertermous T, Ashley EA, Kohl P. Load-dependent effects of apelin on murine cardiomyocytes. Prog Biophys Mol Biol 2017/130:333-343
- Decher N, Ortiz-Bonnin B [...] Seemann G, Peyronnet R, Zumhagen S, Bustos D, Kockskämper J, Kohl P [...] Schulze-Bahr E. Sodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia. EMBO Mol Med 2017/9:403-414
- Peyronnet R, Nerbonne J, Kohl P. Cardiac mechano-gated ion channels and arrhythmias. Circ Res 2016/118:311-329
- Peyronnet R*, Martins JR* [...] Patel A. Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells. EMBO Rep 2013/14:1143-8
- Peyronnet R, Sharif-Naeini R [...] Duprat F. Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K2P channels. Cell Rep 2012/1:1-10
- Bagriantsev SN, Peyronnet R, Clark KA, Honoré E, Minor DL Jr. Multiple modalities converge on a common gate to control K2P channel function. EMBO J 2011/30:3594-606
- Bagriantsev SN, Peyronnet R, Clark KA, Honoré E, Minor DL Jr. Multiple modalities converge on a common gate to control K2P channel function. EMBO Journal 2011/30:3594-606
- Haswell ES* Peyronnet R*, Barbier-Brygoo H, Meyerowitz EM and Frachisse J-M. Two MscS homologs provide mechanosensitive channel activities in the Arabidopsis root. Curr Biol 2008/18:730–734
*these authors contributed equally