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Klinik für Psychiatrie und Psychotherapie

Research group Fiebich

Neurochemistry and Neuroimmunology
Research group
leader:
Dr. Bernd Fiebich
Phone: +49 (0)761 270 - 68980
Email: bernd.fiebich@uniklinik-freiburg.de
Group members: Dr. Inga Herpfer (M.D.)
Soraya Wilke Saliba (Ph.D.)
Florian Ferver (M.D. student)
Matthias Apweiler (M.D. student)
Jana Streyczek (M.D. student)
Victoria Eugenia Garcia Perez (Master student, International Master Program in Biomedical Sciences (IMBS)

 
We are frequently offering , M.D. theses (med. Doktorarbeiten), Internships / Master / Diploma Thesis positions.
For more informations, please contact: bernd.fiebich@uniklinik-freiburg.de

Research focus

Our research group is interested in various aspects of neuroinflammtion and neurodegeneration related to aging.
We are studying in detail the arachidonic acid cascade in microglia with a focus on Prostaglanin E2/D2 and the enzymes involved in their synthesis (COX, mPGES, PGDS).
Another major focus of our group is the role of miRNAs in neuroinflammation, neurodegeneration and peripheral blood cells (monocytes, lymphocytes, thrombocytes).
We also investigate the effects of conventional psychotropic drugs on tachykininergic systems as well as the effects of tachykinin receptor antagonists on monoaminergic neurotransmission and on behaviour in mice.

Research projects

  • Neuroinflammation
  • Psychoneuroendocrinology
  • Alzheimer’s disease and neurodegeneration

Cooperations

  • miRNA: Dr. C. Stratz/Dr. T. Nuehrenberg (University Heart Center Bad Krozingen), Dr. A Höllig (University Hospital Aachen) 
  • Nutrition and healthy aging: Prof. M. Huell (ZFP Emmendingen), Dr. G. Eckert (University of Frankfurt) 
  • Tachykinergic systems: Prof. K. Lieb (Department of Psychiatry and Psychotherapy, University Medical Centre Mainz), Prof. N. Singewald (Neuropharmacology, University of Innsbruck, Austria)
  • Neuroinflammation and Neurodegeneration (Prof. Eduardo Munoz (University of Cordoba, Spain), Prof. Antonio de Oliveira (University of Belo Horizonte, Brasil), Prof. Eduardo Candelario-Jalil (University of Florida, Gainesville, Florida, USA).

Selected recent papers

  • Gargouri B, Boukholda K, Kumar A, Benazzouz A, Fetoui H, Bouchard M., Fiebich BL Bifenthrin insecticide promotes oxidative stress and increases inflammatory mediators in human neuroblastoma cells through NF-kappaB pathway. Toxicol In Vitro. 2020 Jun;65:104792. doi.org/10.1016/j.tiv.2020.104792. Epub 2020 Feb 13.
  • Saliba SW, Bonifacino T, Serchov T, Bonanno G, de Oliveira ACP, Fiebich BL. Neuroprotective Effect of AM404 Against NMDA-Induced Hippocampal Excitotoxicity. Front Cell Neurosci. 2019 Dec 20;13:566. doi.org/10.3389/fncel.2019.00566. eCollection 2019. PMID: 31920563 Free PMC article.
  • Gargouri B, Bouchard M, Saliba SW, Fetoui H, Fiebich BL. Repeated bifenthrin exposure alters hippocampal Nurr-1/AChE and induces depression-like behavior in adult rats. Behav Brain Res. 2019 Sep 16;370:111898. doi.org/10.1016/j.bbr.2019.04.012. Epub 2019 Apr 9. PMID: 30978409
  • Saliba SW, Jauch H, Gargouri B, Keil A, Hurrle T, Volz N, Mohr F, van der Stelt M, Bräse S, Fiebich BL.  Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells.  J Neuroinflammation. 2018 Nov 19;15(1):322. doi.org/10.1186/s12974-018-1362-7. PMID: 30453998 Free PMC article.
  • Fiebich BL, Batista CRA, Saliba SW, Yousif NM, de Oliveira ACP. Role of Microglia TLRs in Neurodegeneration.  Front Cell Neurosci. 2018 Oct 2;12:329. doi.org/10.3389/fncel.2018.00329. eCollection 2018. PMID: 30333729 Free PMC article.
  • Gargouri B, Yousif NM, Bouchard M, Fetoui H, Fiebich BL. Inflammatory and cytotoxic effects of bifenthrin in primary microglia and organotypic hippocampal slice cultures.  J Neuroinflammation. 2018 May 24;15(1):159. doi.org/10.1186/s12974-018-1198-1. PMID: 29793499 Free PMC article.
  • Alleviation of Microglial Activation Induced by p38 MAPK/MK2/PGE2 Axis by Capsaicin: Potential Involvement of other than TRPV1 Mechanism/s. Bhatia HS, Roelofs N, Muñoz E, Fiebich BL. Sci Rep. 2017 Dec;7(1):116.  
  • Bhatia HS, Baron J, Hagl S, Eckert GP, Fiebich BL. Rice bran derivatives alleviate microglia activation: possible involvement of MAPK pathway. J Neuroinflammation. 2016 Jun 14;13(1):148.
  • de Oliveira AC, Yousif NM, Bhatia HS, Hermanek J, Huell M, Fiebich BL. Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia. J. Neuroinflammation. 2016 Jan 18;13(1):11. doi.org/10.1186/s12974-015-0473-7.
  • Kumar A, Bhatia HS, de Oliveira AC, Fiebich BL. microRNA-26a modulates inflammatory response induced by toll-like receptor 4 stimulation in microglia. J Neurochem. 2015 Dec;135(6):1189-202. doi.org/10.1111/jnc.13364.  
  • Nizar M. Yousif, Antonio Carlos Pinheiro de Oliveira, Simone Brioschi, Michael Huell, Knut Biber and Bernd L. Fiebich. Activation of EP2 receptor suppresses Poly(I:C) and LPS-mediated inflammation in primary microglia and organotypic hippocampal slice cultures: Contributing role for  MAPKs, GLIA 2017 (in press).  
  • Saliba SW, Vieira EL, Santos RP, Candelario-Jalil E, Fiebich BL, Vieira LB, Teixeira AL, de Oliveira AC. Neuroprotective effects of intrastriatal injection of rapamycin in a mouse model of excitotoxicity induced by quinolinic acid. Journal of Neuroinflammation, v.14, p.25, 2017.

Publications in PubMed

Funding

  • BMWi/AIF: AGEsense: Determination, function, and pharmaclogical intervention of the synthesis of Advanced Glycation End Products (AGEs)
  • BMBF (TUNGER-36): Cooperation project with the University of Sfax, Tunisia: Mechanism- based approaches for improved health risk assessment of synthetic pyrethroids in the CNSD

Klinik für Psychiatrie und Psychotherapie

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79104 Freiburg

Information: 0761 270-65010


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