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Klinik für Psychiatrie und Psychotherapie

Research group Fiebich

Neurochemistry, Neuroimmunology and molecular Neurobiology related to aging and psychiatric diseases
Research group
leader:
Dr. Bernd Fiebich
Phone: +49 (0)761 270 - 68980
Email: bernd.fiebich@uniklinik-freiburg.de
Group members:

Dr. Inga Herpfer (M.D.)
Dr. Harsharan Bhatia (Ph.D.)
Nizar Yousif (Ph.D. student)
Soraya Wilke Saliba (Ph.D. student)
Brahim Gargouri (Ph.D. student)
Agnes Ball (M.D. student)
Paula Isidora (master student)

 
We are frequently offering , M.D. theses (med. Doktorarbeiten), Internships / Master / Diploma Thesis positions.
For more informations, please contact: bernd.fiebich@uniklinik-freiburg.de

Research focus

Our research group is interested in various aspects of neuroinflammtion and neurodegeneration related to aging.
We are studying in detail the arachidonic acid cascade in microglia with a focus on Prostaglanin E2/D2 and the enzymes involved in their synthesis (COX, mPGES, PGDS).
Another major focus of our group is the role of miRNAs in neuroinflammation, neurodegeneration and peripheral blood cells (monocytes, lymphocytes, thrombocytes).
We also investigate the effects of conventional psychotropic drugs on tachykininergic systems as well as the effects of tachykinin receptor antagonists on monoaminergic neurotransmission and on behaviour in mice.

Research projects

Ongoing projects

  • Prostaglandins/cyclooxygenase
  • Microglia
  • Neuropeptides including tachykininergic systems
  • Neuroinflammation
  • Neurotransmitter
  • miRNA (microRNA) in neurodegeneration, inflammation, and microglia activation
  • Nutrition and healthy aging
  • Glycosylation end products and their role in aging and neurodegeneration (Projekt AGESense)
  • Enviromental-stress factors and their impact on behavior and neuroinflamation (Projekt TUNGER-36)

Cooperations

  • miRNA: Dr. C. Stratz/Dr. T. Nuehrenberg (University Heart Center Bad Krozingen), Dr. A Höllig (University Hospital Aachen) 
  • Nutrition and healthy aging: Prof. M. Huell (Gerontology, Freiburg), Dr. G. Eckert (University of Frankfurt) 
  • Tachykinergic systems: Prof. K. Lieb (Department of Psychiatry and Psychotherapy, University Medical Centre Mainz), Prof. N. Singewald (Neuropharmacology, University of Innsbruck, Austria)
  • Neuroinflammation and Neurodegeneration (Prof. Eduardo Munoz (University of Cordoba, Spain), Prof. Antonio de Oliveira (University of Belo Horizonte, Brasil), Prof. Eduardo Candelario-Jalil (University of Florida, Gainesville, Florida, USA).

Selected recent papers

  • Alleviation of Microglial Activation Induced by p38 MAPK/MK2/PGE2 Axis by Capsaicin: Potential Involvement of other than TRPV1 Mechanism/s. Bhatia HS, Roelofs N, Muñoz E, Fiebich BL. Sci Rep. 2017 Dec;7(1):116.  
  • Bhatia HS, Baron J, Hagl S, Eckert GP, Fiebich BL. Rice bran derivatives alleviate microglia activation: possible involvement of MAPK pathway. J Neuroinflammation. 2016 Jun 14;13(1):148.
  • de Oliveira AC, Yousif NM, Bhatia HS, Hermanek J, Huell M, Fiebich BL. Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia. J. Neuroinflammation. 2016 Jan 18;13(1):11. doi: 10.1186/s12974-015-0473-7.
  • Kumar A, Bhatia HS, de Oliveira AC, Fiebich BL. microRNA-26a modulates inflammatory response induced by toll-like receptor 4 stimulation in microglia. J Neurochem. 2015 Dec;135(6):1189-202. doi: 10.1111/jnc.13364.  
  • Nizar M. Yousif, Antonio Carlos Pinheiro de Oliveira, Simone Brioschi, Michael Huell, Knut Biber and Bernd L. Fiebich. Activation of EP2 receptor suppresses Poly(I:C) and LPS-mediated inflammation in primary microglia and organotypic hippocampal slice cultures: Contributing role for  MAPKs, GLIA 2017 (in press).  
  • Saliba SW, Vieira EL, Santos RP, Candelario-Jalil E, Fiebich BL, Vieira LB, Teixeira AL, de Oliveira AC. Neuroprotective effects of intrastriatal injection of rapamycin in a mouse model of excitotoxicity induced by quinolinic acid. Journal of Neuroinflammation, v.14, p.25, 2017.

Publications in PubMed

Funding

  • Alzheimer Foundation (AFI): MikroRNS Profilierung von Monozyten von Alzheimer-Patienten
  • Herman-Stiftung: Role of 5-Ht3 receptors in inflammation
  • DFG CA 115/5-4 „Regulation der Expression, Signaltransduktion und Funktion von Adenosinrezeptoren im Zentralnervensystem“ In collaboration with section Psychopharmakotherapy
  • Humbold-Foundation, Industrial partners

Klinik für Psychiatrie und Psychotherapie

Hauptstraße 5
79104 Freiburg

Information: 0761 270-65010


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