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Klinik für Psychiatrie und Psychotherapie

Research group Domschke

Psychiatric Genetics and Epigenetics
Research group leader:Prof. Dr. Dr. Katharina Domschke
Phone: +49 (0)761 270 - 65060
Email: katharina.domschke@uniklinik-freiburg.de

Secretariat: Sigrid Herbst
Phone: +49 (0)761 270 - 65060
Email: sigrid.herbst@uniklinik-freiburg.de
Group members:
Freiburg







Würzburg

Dr. Miriam Schiele, Dipl.-Psych.
Phone: +49 (0)761 270 - 66691
Email: miriam.schiele@uniklinik-freiburg.de 

Dr. Christiane Ziegler, M.Sc.
Phone: +49 (0)761 270 - 66691
Email: christiane.ziegler@uniklinik-freiburg.de

Carola Gagel, BTA
Michael G. Gottschalk, Ph.D.
Leonie Kollert, M.Sc.
Christoph Schartner, M.Sc.
Nicole Schmidt, MTA
Saskia Stonawski, Dipl.-Psych.
Melanie Vietz, M.Sc.

Research focus

  • Genetics and epigenetics of anxiety disorders and depression
    Anxiety disorders and depression are among the most frequent mental disorders with lifetime prevalence rates of about 20%. Twin studies indicate a considerable heritability (40-87%) of these disorders with contributions from several different genes, which interact with each other as well as with environmental factors in a complex-genetic model. Additionally, epigenetic mechanisms such as DNA methylation have become a central focus in psychiatric research as a dynamic link between genetic make-up and environmental stress shaping the overall disease risk. Our aims are to identify genetic and epigenetic factors as well as their interplay with environmental influences contributing to the development of anxiety disorders and depression.
  • (Epi)genetics of intermediate phenotypes of anxiety disorders and depression
    The influence of genetic factors on anxiety and depressive disorders can be further specified by the consideration of so-called ‘intermediate phenotypes’. Intermediate phenotypes comprise heritable neurobiological or neuropsychological traits (e.g. anxiety sensitivity, neural activation patterns, startle reflex) that are linked to the disorder of interest, and, unlike the overall categorical disease phenotype, are dimensional, closely defined constructs and are therefore considered to be closer to the underlying genotype. Their investigation constitutes another central focus of our group.
  • Therapy(epi)genetics of anxiety disorders and depression
    In the treatment of anxiety disorders and depression, efficacious pharmacological (e.g. SSRIs, SNRIs) and psychotherapeutic (e.g. CBT) options are available. However, treatment-resistance is a common problem in clinical practice, with about 30% of patients responding insufficiently to the initial treatment. Our workgroup aims to identify predictive genetic and epigenetic markers of favorable therapy response, as well as to elucidate epigenetic mechanisms of change in the course of treatment towards the development of a “precision medicine” approach corresponding to a patient’s individual risk factor constellation.
  • Prediction and prevention of anxiety disorders and depression
    Anxiety and depressive disorders present with high chronicity and confer a substantial socioeconomic burden. They are highly comorbid, both with each other as well as with other mental disorders. Anxiety disorders can already manifest early in childhood and are characterized by high progression towards other anxiety disorders or other psychiatric disorders (e.g. depression) across the lifespan. Therefore, next to the identification of risk factors, preventive measures are needed in order to increase resilience in at-risk populations and are thus clinically and biologically investigated by our group.
     

Research projects

Ongoing

Recently completed

  • Epigenetic profiling of anxiety: the role of DNA methylation in the pathogenesis and therapeutic mechanisms of anxiety disorders (SFBTRR-58, project C02, 2nd funding period 2013-2016; together with Prof. Dr. K.P. Lesch, Prof. Dr. J. Deckert)
  • Anxiety and emotional perception – Modulation by the adenosine, dopamine and endocannabinoid system (SFBTRR-58, project C02, 1st funding period 2008-2012; together with Prof. Dr. J. Deckert)
     

Selected publications

  • Baune BT, Hohoff C, Berger K, Neumann A, Mortensen S, Roehrs T, Deckert J, Arolt V, Domschke K (2008) Association of the COMT val158met variant with antidepressant treatment response in Major Depression. Neuropsychopharmacology 33:924-932.
  • Domschke K, Akhrif A, Bajer C, Mainusch M, Romanos M, Winkelmann J, Zimmer C, Neufang S (2015) Neuropeptide S receptor gene modulates the development of fronto-limbic effective connectivity. Cereb Cortex, bhv259.
  • Domschke K, Gajewska A, Winter B, Herrmann MJ, Warrings B, Mühlberger A, Wosnitza K, Glotzbach E, Conzelmann A, Dlugos A, Fobker M, Jacob C, Arolt V, Reif A, Pauli P, Zwanzger P, Deckert J (2012a) ADORA2A gene variation, caffeine and emotional processing – a multi-level interaction on startle reflex, Neuropsychopharmacology 37: 759-769. 
  • Domschke K, Reif A, Weber H, Richter J, Hohoff C, Ohrmann P, Pedersen A, Bauer J, Suslow T, Kugel H, Heindel W, Baumann C, Klauke B, Jacob C, Maier W, Fritze J, Bandelow B, Krakowitzky P, Rothermundt M, Erhardt A, Binder EB, Holsboer F, Gerlach AL, Kircher T, Lang T, Alpers GW, Ströhle A, Fehm L, Gloster AT, Wittchen HU, Arolt V, Pauli P, Hamm A, Deckert J (2011) Neuropeptide S receptor gene – converging evidence for a role in panic disorder. Mol Psychiatry 16:938-948.
  • Domschke K, Tidow N, Kuithan H, Schwarte K, Klauke B, Ambrée O, Reif A, Schmidt H, Arolt V, Kersting A, Zwanzger P, Deckert J (2012b) Monoamine oxidase A gene DNA hypomethylation - a risk factor for panic disorder? Int J Neuropsychopharmacol 15:1217-1228.
  • Neufang S, Geiger M, Homola G, Mahr M, Nowak J, Reif A, Pauli P, Romanos M, Solymosi L, Deckert J, Domschke K (2015) Modulation of prefrontal functioning in attentional neural networks by NPSR1 gene variation. NeuroImage 14:199-206.
  • Ziegler C, Dannlowski U, Braeuer D, Stevens S, Laeger I, Wittmann H, Tidow N, Mahr M, Kugel H, Heindel W, Dobel C, Hurlemann R, Reif A, Lesch KP, Arolt V, Gerlach A, Hoyer J, Deckert J, Zwanzger P, Domschke K (2015) Oxytocin receptor (OXTR) gene methylation – converging evidence for a role in social anxiety, Neuropsychopharmacology 40:1528-1538.
  • Ziegler C, Richter J, Mahr M, Gajewska A, Schiele MA, Gehrmann A, Schmidt B, Lesch KP, Lang T, Helbig-Lang S, Pauli P, Kircher T, Reif A, Rief W, Vossbeck-Elsebusch AN, Arolt V, Wittchen HU, Hamm AO, Deckert J, Domschke K (2016) MAOA gene hypomethylation in panic disorder-reversibility of an epigenetic risk pattern by psychotherapy, Transl Psychiatry 6:e773.

PubMed

Funding

  • Deutsche Forschungsgemeinschaft (DFG), Collaborative Research Centre SFBTRR-58 “Fear, Anxiety, Anxiety Disorders”
  • Bundesministerium für Bildung und Forschung (BMBF), PROTECT-AD
  • European Union (EU), EUSARNAD, FP7-PEOPLE-2010-IRSES
  • Interdisziplinäres Zentrum für Klinische Forschung (IZKF), Würzburg

Klinik für Psychiatrie und Psychotherapie

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79104 Freiburg

Information: 0761 270-65010


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