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Department of Radiology - Medical Physics

Hyperpolarization

Publications

For most recent information, see PubMed (link).

2014

  • Hövener JB, Knecht S, Schwaderlapp N, Hennig J, von Elverfeldt D: "Continuous re-hyperpolarization of nuclear spins using parahydrogen: theory and experiment", ChemPhysChem, 2014, 15(12):2451-7, DOI:10.1002/cphc.201402177, → open access.
  • Ludwig UA, Klausmann F, Baumann S, Honal M, Hövener JB, König D, Deibert P, Büchert M: "Whole-body MRI-based fat quantification: A comparison to air displacement plethysmography", Journal of Magnetic Resonance Imaging, 2014, 40(6):1437-44, DOI:10.1002/jmri.24509, → open access.
  • Hövener JB, Schwaderlapp N, Borowiak R, Lickert T, Duckett SB, Mewis RE, Adams RW, Burns MJ, Highton LA, Green GG, Olaru A, Hennig J, von Elverfeldt D: "Toward biocompatible nuclear hyperpolarization using signal amplification by reversible exchange: quantitative in situ spectroscopy and high-field imaging", analytical chemistry, 2014, 86(3):1767-74, DOI:10.1021/ac403653q, → open access.

2013

  • Hövener J-B, Schwaderlapp N, Lickert T, Duckett SB, Mewis RE, Highton LAR, Kenny, SM, Green GR, Leibfritz D, Korvink J, Hennig J and von Elverdeldt D: "A Hyperpolarized Equilibrium for Magnetic Resonance", nature communications, 2013, 3946, DOI:10.1038/ncomms3946, → open access.
  • Ludwig U, Klausmann F, Baumann S, Honal M, Hövener J-B, König D, Deibert P, Büchert M: "Whole-body MRI based fat quantification: A comparison to Air Displacement Plenthysmography", Journal of Magnetic Resonance Imaging, 2013, accepted.
  • Hövener J-B, Bär S, Leupold J, Jenne K, Leibritz D, Hennig J, Duckett S, v. Elverfeldt D: “A continuous-flow, high-throughput and –pressure pH2 converter for hyperpolarization in a clinical setting”, NMR in Biomedicine, 2013, 26(2), p. 124-131, DOI: 10.1002/nbm.2827, → open acess.

2012

  • Borowiak R, Schwaderlapp N, Hüthe F, Lickert T, Fischer E, Bär S, Leupold J, Hennig J, v. Elverfeldt D, Hövener J-B: “A Battery-driven, Low-field NMR Unit for Thermally and Hyperpolarized Samples”, Magnetic Resonance Materials in Physics, Biology and Medicine, 2013, 26(5), p. 491-499, → open.
  • Bär S, Lange T, Leibfritz D, Hennig J, v. Elverfeldt D, Hövener J-B: “On the Spin Order Transfer from Parahydrogen to Another Nucelus”, Jorunal of Magnetic Resonance, 2012, 225, p. 25-35, → open access.
  • Hövener J-B, Zwick S, Leupold J, Eisenbeiß AK, Scheifele C, Schellenberger F, Hennig J, v.Elverfeldt D, Ludwig U: “Dental MRI: imaging of soft and solid components without ionizing radiation”, Journal of Magnetic Resonance Imaging, 2012, 36(4), p. 841-846, → open access.

2010

  • Perman W, Bhattacharya P, Leupold J, Lin A., Harris K, Norton V, Hovener JB, Ross BD: “Fast volumetric spatial-spectral MR imaging of hyperpolarized 13C-labeled compounds using multiple echo 3D bSSFP”, Magnetic Resonance Imaging, 2010, 28 (4), p. 459 - 465 → open access.

2009

  • Hövener J-B, Chekmenev E, Harris K, Perman W, Robertson L.W, Ross B.D and Bhattacharya P: “PASADENA Hyperpolarization of 13C Biomolecules: Equipment Design and Installation”, Magnetic Resonance Materials in Physics, Biology and Medicine 22 (2): 111 – 121, 2009.→ open access.
  • Hövener J-B, Chekmenev E, Harris K, Perman W, Tran T, Ross B.D and Bhattacharya P: “Quality Assurance of PASADENA Hyperpolarization for 13C Biomolecules”. Magnetic Resonance Materials in Physics, Biology and Medicine 22 (2): 123 – 134, 2009. → open access

2008 and before

  • Hövener J-B, Rigotti D, Amann M, Liu S, Babb J.S, Bachert P, Grossman R.I and Gonen O: “Whole-Brain N acetylaspartate MR Spectroscopic Quantification - Performance Comparison of Metabolite Versus Lipid Nulling”, American Journal of Neuroradiology 29: 1441-1445, 2008.
  • Chekmenev E, Hövener J-B, Norton V.A, Harris K, Batchelder L.S, Bhattacharya P, Ross B.D and Weitekamp D.P: “PASADENA Hyperpolarization of Succinic Acid for MRI and NMR spectroscopy”. Journal of the American Chemical Society 130: 4212 – 4213, 2008. → open access.
  • Xu V, Chan H, Lin A, Sailasuta N, Valencerina S, Tran T, Hovener, J, Ross B.D: MR Spectroscopy in Diagnosis and Neurological Decision-Making. Seminars in Neurology 28 (4), 2008.
  • Hövener J-B, Bachert P: “Experimental approach to determine non-invasively the total content of N-acetyl-L-aspartate (NAA) in the human brain”. Traditional poster for the Int. Conference of Medical Physics 2005, Nürnberg, Germany, and published in Biomedizinische Technik, 2005: 50 (suppl. vol. 1, part 1): 1178 – 1179.

Conference Abstracts (selected)

  • Schwaderlapp N, Lickert T, Baer S, Hennig J, Elverfeldt D v. and Hövener J-B. "Earth field MRI Using Continuous SABRE Hyperpolarization" In: Proceedings of the Annual Meeting of the International Society of Magnetic Resonance in Medicine, Salt Lake City, USA, 2013.  
  • Hövener, J-B, Schwaderlapp N, Lickert T, Leibfritz D, Borowiak R, Duckett SB, Hennig J, Elverfeldt D v. "A Hyperpolarized Equilibrium". In: Proceedings of the Experimental NMR Conference, Asilomar, USA, 2013.
  • Hövener J-B, et al.: “How about pH2 in solution? Continuous hyperpolarization using SABRE”. Gordon Research Coference 2012, Waterville, Maine, USA.
  • Hövener J-B, Chekmenev E, et al.: “Quality assurance of PASADENA hyperpolarization for 13C Biomolecules”. Experimental NMR Conference (ENC) 2008, Asilomar, USA.
  • Hövener, Jan-Bernd: "Strategies to prolong T1 in hyperpolarized 15N and 13C nuclei”. Proceedings of the 16th Scientific Meeting ISMRM 2008, Toronto, Canada.
  • Hövener J-B,Chekmenev E, et al.: “Reproducibility and quality assurance in hyperpolarized 13C MRI and MRS”. Proceedings of the 15th Scientific Meeting ISMRM 2007, Berlin, Germany.
  •  Hövener J-B, Lin A, et al.: “Neurospectroscopy will miss the boat – AGAIN: The unmet need for universal standards and a database”. Proceedings of the 15th Scientific Meeting ISMRM 2007, Berlin, Germany.
  • Hövener J-B, Bachert P: “Experimental approach to determine non-invasively the total content of N-acetyl-L-aspartate (NAA) in the human brain”. Int. Conference of Medical Physics 2005, Nürnberg, Germany, and published in Biomedizinische Technik, 2005: 50 (suppl. vol. 1, part 1): 1178 – 1179.

Prof. Dr. Jan-Bernd Hövener
Head, Section for Biomedical Imaging and MOIN CC
Head, Emmy Noether Group Molecular and Metabolic MRI

Am Botanischen Garten 14
D-24118 Kiel

phone:  +49 (0) 431 880-5832
fax:       +49 (0) 431 880-5852

Office Freiburg
Killianstr. 5a
D-79106 Freiburg
phone:  +49 (0) 761 270-93910
fax:       +49 (0) 431 880-38310

email: jan.hoevener@rad.uni-kiel.de 

twitter: @jbhoevener