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Department of Radiology - Medical Physics

Hyperpolarization

Publications

2021

  • S. Berner, A.B. Schmidt, F. Ellermann, S. Korchak, E. Chekmenev, S. Glöggler, D. von Elverfeldt, J. Hennig, J.-B. Hövener: "High Field Parahydrogen Induced Polarization of Succinate and Phospholactate", Phys. Chem. Chem. Phys. 2021, advance article. DOI: 10.1039/D0CP06281B.

2020

  • C. A. Muller, C. Hundshammer, M. Brauer, J. G. Skinner, S. Berner, J. Leupold, S. Duwel, S. G. Nekolla, S. Mansson, A. E. Hansen, D. von Elverfeldt, J. H. Ardenkjaer-Larsen, F. Schilling, M. Schwaiger, J. Hennig, J.-B. Hovener: "Dynamic 2D and 3D mapping of pyruvate to lactate conversion in vivo with
    ectent me-bSSFP on a 3T", NMR in Biomedicine 2020, e4291. DOI: 10.1002/nbm.4291
  • S. Mamone, A.B. Schmidt, N. Schwaderlapp, T. Lange, D. von Elverfeldt, J. Hennig, S. Glöggler: "Localized Singlet-Filtered Magnetic Resonance Spectroscopy in vivo", NMR Biomed. 2020, e4400. DOI: 10.1002/nbm.4400.
  • C.A. Müller: "Real-time metabolic imaging of pyruvate and lactate using hyperpolarised 13C magnetic resonance spectroscopic imaging with ME-bSSFP : a method of clinical cancer imaging", PhD thesis, University of Freiburg 2020. DOI: 10.6094/UNIFR/175618.
  • S. Berner: "Parahydrogen hyperpolarized metabolites and spin dynamics at high magnetic field", PhD thesis, University of Freiburg 2020. DOI: 10.6094/UNIFR/166544.
  • P. Rovedo: "1H and 15N hyperpolarization using SABRE : experimental approaches and hardware designs for continuous and batch hyperpolarization", PhD thesis, University of Freiburg 2020. DOI: 10.6094/UNIFR/166207.
  • A.B. Schmidt: "Liquid-state nuclear hyperpolarization without a polarizer : synthesis amid the magnet bore allows a dramatically enhanced nuclear alignment", PhD thesis, University of Freiburg 2020. DOI: 10.6094/UNIFR/165763.
  • B. Joalland, A.B. Schmidt, M.S.H. Kabir, N.V. Chukanov, K.V. Kovtunov, I.V. Koptyug, J. Hennig, J.-B. Hövener, E.Y. Chekmenev: "Pulse-Programmable Magnetic Field Cycling of Parahydrogen-Induced Polarization by Side Arm Hydrogenation", Anal. Chem. 2020, 92, 1, 1340–1345. DOI: 10.1021/acs.analchem.9b04501.

2019

  • S. Knecht: "On the interplay of spin dynamics and chemical kinetics in the nuclear spin hyperpolarization technique signal amplification by reversible exchange (SABRE): a simulation and experimental NMR study", PhD thesis, University of Freiburg 2019. DOI: 10.6094/UNIFR/154759
  • A.B. Schmidt, J. Wörner, A. Pravdivtsev, S. Knecht, H. Scherer, S. Weber, J. Hennig, D. von Elverfeldt, J.-B. Hövener: "Lifetime of Parahydrogen in Aqueous Solutions and Human Blood", ChemPhysChem 2019, 20, 19, 2408-2412. DOI: 10.1002/cphc.201900670.
  • S. Knecht, K.L. Ivanov: "Quantitative quantum mechanical approach to SABRE hyperpolarization at high magnetic fields", J. Chem. Phys. 2019, 150, 124106. DOI: 10.1063/1.5084129
  • S. Knecht, S. Hadjiali, D.A. Barskiy, A. Pines, G. Sauer, A.S. Kiryutin, K.L. Ivanov, A.V. Yurkovskaya, G. Buntkowsky: "Indirect Detection of Short-Lived Hydride Intermediates of Iridium N-Heterocyclic Carbene Complexes via Chemical Exchange Saturation Transfer Spectroscopy", J. Phys. Chem. C 2019, 123, 26, 16288–16293. DOI: 10.1021/acs.jpcc.9b04179.
  • S. Knecht, A.S. Kiryutin, A.V. Yurkovskaya, K.L. Ivanov: "Efficient conversion of anti-phase spin order of protons into 15N magnetisation using SLIC-SABRE", Molecular Physics 2019, 117, 19, 2762-2771. DOI: 10.1080/00268976.2018.1515999.
  • D.A. Barskiy, S. Knecht, A.V. Yurkovskaya, K.L. Ivanov: "SABRE: Chemical kinetics and spin dynamics of the formation of hyperpolarization", Prog Nucl Magn Reson Spec 2019, 114-115, 33-70. DOI: 10.1016/j.pnmrs.2019.05.005. 
  • S. Berner, A.B. Schmidt, M. Zimmermann, A. N. Pravdivtsev, S. Glöggler, J. Hennig, D. von Elverfeldt, J.-B. Hövener: "SAMBADENA Hyperpolarization of 13C‐Succinate in an MRI: Singlet‐Triplet Mixing Causes Polarization Loss", ChemistryOpen 2019, 8, 728–736. DOI: 10.1002/open.201900139.

2018

  • A.B. Schmidt, S. Berner, M. Braig, M. Zimmermann, J. Hennig, D. von Elverfeldt, J.-B. Hövener: "In Vivo 13C-MRI Using SAMBADENA", PLOS ONE 2018, 13, 7. DOI: 10.1371/journal.pone.0200141.
  • S. Knecht, A.S. Kiryutin, A.V. Yurkovskaya, K.L. Ivanov: "Mechanism of spontaneous polarization transfer in high-field SABRE experiments", JMR 2018, 287, 74-81. DOI: 10.1016/j.jmr.2017.12.018
  • S. Knecht, A.S. Kiryutin, A.V. Yurkovskaya, K.L. Ivanov: "Re-polarization of nuclear spins using selective SABRE-INEPT", JMR 2018, 287, 10-14. DOI: 10.1016/j.jmr.2017.12.010.
  • J.G. Skinner, L. Menichetti, A. Flori, A. Dost, A.B. Schmidt, M. Plaumann, F.A. Gallagher, J.-B. Hövener: "Metabolic and Molecular Imaging with Hyperpolarised Tracers", Molecular Imaging and Biology, 2018, 20, 902-918. DOI: 10.1007/s11307-018-1265-0.

2017

  • A.B. Schmidt, S. Berner, W. Schimpf, C. Müller, T. Lickert, N. Schwaderlapp, S. Knecht, J.G. Skinner, A. Dost, P. Rovedo, J. Hennig, D. von Elverfeldt, J.-B. Hövener: "Liquid-state carbon-13 hyperpolarization generated in an MRI system for fast imaging", Nat. Commun. 2017, 8, 14535. DOI: 10.1038/ncomms14535.

2016

  • A.B. Schmidt, D.L. Andrews, A. Rohrbach, C. Gohn-Kreuz, V.N. Shatokhin, V.G. Kiselev, J. Hennig, D. von Elverfeldt, J.-B. Hövener: "Do Twisted Laser Beams Evoke Nuclear Hyperpolarization?", Journal of Magnetic Resonance 2016, 268, 58–67. DOI: 10.1016/j.jmr.2016.04.015.
  • S. Knecht, A.N. Pravdivtsev, J.-B. Hövener, A.V. Yurkovskaya, K.L. Ivanov: "Quantitative description of the SABRE process: rigorous consideration of spin dynamics and chemical exchange", RSC Adv., 2016,6, 24470-24477. DOI: 10.1039/C5RA28059A
  • P. Rovedo, S. Knecht, T. Bäumlisberger, A.-L. Cremer, S. B. Duckett, R.E. Mewis, G.G.R. Green, M. J. Burns, P.J. Rayner, D. Leibfritze, J.G. Korvink, J. Hennig, G. Pütz, D.v. Elverfeldt, J.-B. Hövener: "Molecular MRI in the Earth’s Magnetic Field Using Continuous Hyperpolarization of a Biomolecule in Water", The Journal of Physical Chemistry B 2016, 120, 25, 5670–5677. DOI: 10.1021/acs.jpcb.6b02830

2014

  • Hövener JB, Knecht S, Schwaderlapp N, Hennig J, von Elverfeldt D: "Continuous re-hyperpolarization of nuclear spins using parahydrogen: theory and experiment", ChemPhysChem, 2014, 15(12):2451-7, DOI:10.1002/cphc.201402177, → open access.
  • Ludwig UA, Klausmann F, Baumann S, Honal M, Hövener JB, König D, Deibert P, Büchert M: "Whole-body MRI-based fat quantification: A comparison to air displacement plethysmography", Journal of Magnetic Resonance Imaging, 2014, 40(6):1437-44, DOI:10.1002/jmri.24509, → open access.
  • Hövener JB, Schwaderlapp N, Borowiak R, Lickert T, Duckett SB, Mewis RE, Adams RW, Burns MJ, Highton LA, Green GG, Olaru A, Hennig J, von Elverfeldt D: "Toward biocompatible nuclear hyperpolarization using signal amplification by reversible exchange: quantitative in situ spectroscopy and high-field imaging", analytical chemistry, 2014, 86(3):1767-74, DOI:10.1021/ac403653q, → open access.

2013

  • Hövener J-B, Schwaderlapp N, Lickert T, Duckett SB, Mewis RE, Highton LAR, Kenny, SM, Green GR, Leibfritz D, Korvink J, Hennig J and von Elverdeldt D: "A Hyperpolarized Equilibrium for Magnetic Resonance", nature communications, 2013, 3946, DOI:10.1038/ncomms3946, → open access.
  • Ludwig U, Klausmann F, Baumann S, Honal M, Hövener J-B, König D, Deibert P, Büchert M: "Whole-body MRI based fat quantification: A comparison to Air Displacement Plenthysmography", Journal of Magnetic Resonance Imaging, 2013, accepted.
  • Hövener J-B, Bär S, Leupold J, Jenne K, Leibritz D, Hennig J, Duckett S, v. Elverfeldt D: “A continuous-flow, high-throughput and –pressure pH2 converter for hyperpolarization in a clinical setting”, NMR in Biomedicine, 2013, 26(2), p. 124-131, DOI: 10.1002/nbm.2827, → open acess.

2012

  • Borowiak R, Schwaderlapp N, Hüthe F, Lickert T, Fischer E, Bär S, Leupold J, Hennig J, v. Elverfeldt D, Hövener J-B: “A Battery-driven, Low-field NMR Unit for Thermally and Hyperpolarized Samples”, Magnetic Resonance Materials in Physics, Biology and Medicine, 2013, 26(5), p. 491-499, → open.
  • Bär S, Lange T, Leibfritz D, Hennig J, v. Elverfeldt D, Hövener J-B: “On the Spin Order Transfer from Parahydrogen to Another Nucelus”, Jorunal of Magnetic Resonance, 2012, 225, p. 25-35, → open access.
  • Hövener J-B, Zwick S, Leupold J, Eisenbeiß AK, Scheifele C, Schellenberger F, Hennig J, v.Elverfeldt D, Ludwig U: “Dental MRI: imaging of soft and solid components without ionizing radiation”, Journal of Magnetic Resonance Imaging, 2012, 36(4), p. 841-846, → open access.

2010

  • Perman W, Bhattacharya P, Leupold J, Lin A., Harris K, Norton V, Hovener JB, Ross BD: “Fast volumetric spatial-spectral MR imaging of hyperpolarized 13C-labeled compounds using multiple echo 3D bSSFP”, Magnetic Resonance Imaging, 2010, 28 (4), p. 459 - 465 → open access.

2009

  • Hövener J-B, Chekmenev E, Harris K, Perman W, Robertson L.W, Ross B.D and Bhattacharya P: “PASADENA Hyperpolarization of 13C Biomolecules: Equipment Design and Installation”, Magnetic Resonance Materials in Physics, Biology and Medicine 22 (2): 111 – 121, 2009.→ open access.
  • Hövener J-B, Chekmenev E, Harris K, Perman W, Tran T, Ross B.D and Bhattacharya P: “Quality Assurance of PASADENA Hyperpolarization for 13C Biomolecules”. Magnetic Resonance Materials in Physics, Biology and Medicine 22 (2): 123 – 134, 2009. → open access

2008 and before

  • Hövener J-B, Rigotti D, Amann M, Liu S, Babb J.S, Bachert P, Grossman R.I and Gonen O: “Whole-Brain N acetylaspartate MR Spectroscopic Quantification - Performance Comparison of Metabolite Versus Lipid Nulling”, American Journal of Neuroradiology 29: 1441-1445, 2008.
  • Chekmenev E, Hövener J-B, Norton V.A, Harris K, Batchelder L.S, Bhattacharya P, Ross B.D and Weitekamp D.P: “PASADENA Hyperpolarization of Succinic Acid for MRI and NMR spectroscopy”. Journal of the American Chemical Society 130: 4212 – 4213, 2008. → open access.
  • Xu V, Chan H, Lin A, Sailasuta N, Valencerina S, Tran T, Hovener, J, Ross B.D: MR Spectroscopy in Diagnosis and Neurological Decision-Making. Seminars in Neurology 28 (4), 2008.
  • Hövener J-B, Bachert P: “Experimental approach to determine non-invasively the total content of N-acetyl-L-aspartate (NAA) in the human brain”. Traditional poster for the Int. Conference of Medical Physics 2005, Nürnberg, Germany, and published in Biomedizinische Technik, 2005: 50 (suppl. vol. 1, part 1): 1178 – 1179.

Andreas B. Schmidt
Head of Hyperpolarization

Killianstr. 5a
D-79106 Freiburg

phone:  +49 (0) 761 270-93911
email: andreas.schmidt@uniklinik-freiburg.de