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Department of Radiology - Medical Physics

Hyperpolarization

Publications

For most recent information, see PubMed (link).

2014

  • Hövener JB, Knecht S, Schwaderlapp N, Hennig J, von Elverfeldt D: "Continuous re-hyperpolarization of nuclear spins using parahydrogen: theory and experiment", ChemPhysChem, 2014, 15(12):2451-7, DOI:10.1002/cphc.201402177, → open access.
  • Ludwig UA, Klausmann F, Baumann S, Honal M, Hövener JB, König D, Deibert P, Büchert M: "Whole-body MRI-based fat quantification: A comparison to air displacement plethysmography", Journal of Magnetic Resonance Imaging, 2014, 40(6):1437-44, DOI:10.1002/jmri.24509, → open access.
  • Hövener JB, Schwaderlapp N, Borowiak R, Lickert T, Duckett SB, Mewis RE, Adams RW, Burns MJ, Highton LA, Green GG, Olaru A, Hennig J, von Elverfeldt D: "Toward biocompatible nuclear hyperpolarization using signal amplification by reversible exchange: quantitative in situ spectroscopy and high-field imaging", analytical chemistry, 2014, 86(3):1767-74, DOI:10.1021/ac403653q, → open access.

2013

  • Hövener J-B, Schwaderlapp N, Lickert T, Duckett SB, Mewis RE, Highton LAR, Kenny, SM, Green GR, Leibfritz D, Korvink J, Hennig J and von Elverdeldt D: "A Hyperpolarized Equilibrium for Magnetic Resonance", nature communications, 2013, 3946, DOI:10.1038/ncomms3946, → open access.
  • Ludwig U, Klausmann F, Baumann S, Honal M, Hövener J-B, König D, Deibert P, Büchert M: "Whole-body MRI based fat quantification: A comparison to Air Displacement Plenthysmography", Journal of Magnetic Resonance Imaging, 2013, accepted.
  • Hövener J-B, Bär S, Leupold J, Jenne K, Leibritz D, Hennig J, Duckett S, v. Elverfeldt D: “A continuous-flow, high-throughput and –pressure pH2 converter for hyperpolarization in a clinical setting”, NMR in Biomedicine, 2013, 26(2), p. 124-131, DOI: 10.1002/nbm.2827, → open acess.

2012

  • Borowiak R, Schwaderlapp N, Hüthe F, Lickert T, Fischer E, Bär S, Leupold J, Hennig J, v. Elverfeldt D, Hövener J-B: “A Battery-driven, Low-field NMR Unit for Thermally and Hyperpolarized Samples”, Magnetic Resonance Materials in Physics, Biology and Medicine, 2013, 26(5), p. 491-499, → open.
  • Bär S, Lange T, Leibfritz D, Hennig J, v. Elverfeldt D, Hövener J-B: “On the Spin Order Transfer from Parahydrogen to Another Nucelus”, Jorunal of Magnetic Resonance, 2012, 225, p. 25-35, → open access.
  • Hövener J-B, Zwick S, Leupold J, Eisenbeiß AK, Scheifele C, Schellenberger F, Hennig J, v.Elverfeldt D, Ludwig U: “Dental MRI: imaging of soft and solid components without ionizing radiation”, Journal of Magnetic Resonance Imaging, 2012, 36(4), p. 841-846, → open access.

2010

  • Perman W, Bhattacharya P, Leupold J, Lin A., Harris K, Norton V, Hovener JB, Ross BD: “Fast volumetric spatial-spectral MR imaging of hyperpolarized 13C-labeled compounds using multiple echo 3D bSSFP”, Magnetic Resonance Imaging, 2010, 28 (4), p. 459 - 465 → open access.

2009

  • Hövener J-B, Chekmenev E, Harris K, Perman W, Robertson L.W, Ross B.D and Bhattacharya P: “PASADENA Hyperpolarization of 13C Biomolecules: Equipment Design and Installation”, Magnetic Resonance Materials in Physics, Biology and Medicine 22 (2): 111 – 121, 2009.→ open access.
  • Hövener J-B, Chekmenev E, Harris K, Perman W, Tran T, Ross B.D and Bhattacharya P: “Quality Assurance of PASADENA Hyperpolarization for 13C Biomolecules”. Magnetic Resonance Materials in Physics, Biology and Medicine 22 (2): 123 – 134, 2009. → open access

2008 and before

  • Hövener J-B, Rigotti D, Amann M, Liu S, Babb J.S, Bachert P, Grossman R.I and Gonen O: “Whole-Brain N acetylaspartate MR Spectroscopic Quantification - Performance Comparison of Metabolite Versus Lipid Nulling”, American Journal of Neuroradiology 29: 1441-1445, 2008.
  • Chekmenev E, Hövener J-B, Norton V.A, Harris K, Batchelder L.S, Bhattacharya P, Ross B.D and Weitekamp D.P: “PASADENA Hyperpolarization of Succinic Acid for MRI and NMR spectroscopy”. Journal of the American Chemical Society 130: 4212 – 4213, 2008. → open access.
  • Xu V, Chan H, Lin A, Sailasuta N, Valencerina S, Tran T, Hovener, J, Ross B.D: MR Spectroscopy in Diagnosis and Neurological Decision-Making. Seminars in Neurology 28 (4), 2008.
  • Hövener J-B, Bachert P: “Experimental approach to determine non-invasively the total content of N-acetyl-L-aspartate (NAA) in the human brain”. Traditional poster for the Int. Conference of Medical Physics 2005, Nürnberg, Germany, and published in Biomedizinische Technik, 2005: 50 (suppl. vol. 1, part 1): 1178 – 1179.

Conference Abstracts (selected)

  • Schwaderlapp N, Lickert T, Baer S, Hennig J, Elverfeldt D v. and Hövener J-B. "Earth field MRI Using Continuous SABRE Hyperpolarization" In: Proceedings of the Annual Meeting of the International Society of Magnetic Resonance in Medicine, Salt Lake City, USA, 2013.  
  • Hövener, J-B, Schwaderlapp N, Lickert T, Leibfritz D, Borowiak R, Duckett SB, Hennig J, Elverfeldt D v. "A Hyperpolarized Equilibrium". In: Proceedings of the Experimental NMR Conference, Asilomar, USA, 2013.
  • Hövener J-B, et al.: “How about pH2 in solution? Continuous hyperpolarization using SABRE”. Gordon Research Coference 2012, Waterville, Maine, USA.
  • Hövener J-B, Chekmenev E, et al.: “Quality assurance of PASADENA hyperpolarization for 13C Biomolecules”. Experimental NMR Conference (ENC) 2008, Asilomar, USA.
  • Hövener, Jan-Bernd: "Strategies to prolong T1 in hyperpolarized 15N and 13C nuclei”. Proceedings of the 16th Scientific Meeting ISMRM 2008, Toronto, Canada.
  • Hövener J-B,Chekmenev E, et al.: “Reproducibility and quality assurance in hyperpolarized 13C MRI and MRS”. Proceedings of the 15th Scientific Meeting ISMRM 2007, Berlin, Germany.
  •  Hövener J-B, Lin A, et al.: “Neurospectroscopy will miss the boat – AGAIN: The unmet need for universal standards and a database”. Proceedings of the 15th Scientific Meeting ISMRM 2007, Berlin, Germany.
  • Hövener J-B, Bachert P: “Experimental approach to determine non-invasively the total content of N-acetyl-L-aspartate (NAA) in the human brain”. Int. Conference of Medical Physics 2005, Nürnberg, Germany, and published in Biomedizinische Technik, 2005: 50 (suppl. vol. 1, part 1): 1178 – 1179.

Prof. Dr. Jan-Bernd Hövener
Head, Section for Biomedical Imaging and MOIN CC
Head, Emmy Noether Group Molecular and Metabolic MRI
President, ISMRM German Chapter Section Biomedical Imaging, MOIN CC

Am Botanischen Garten 14
D-24118 Kiel

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