Department of Radiology - Medical Physics

Hybrid Pixel Detector Imaging Lab

We develop compact, multimodal imaging systems based on hybrid pixel detector technology. Our work spans spectral CT, Compton and gamma imaging, and integrated imaging platforms for clinical, preclinical, and emerging applications.

Our central idea is to use a single detector technology paradigm to unify multiple imaging modalities:

• X-ray CT and radiography
• Spectral and photon-counting imaging
• Gamma and Compton imaging
• Hybrid systems combining CT and nuclear imaging

This enables fundamentally new system designs that are:

• Compact and mobile
• Quantitative and spectrally resolved
• Compatible with clinical and intraoperative environments

Core Research Directions

Spectral & Photon-Counting CT
Energy-resolved X-ray imaging for material decomposition, artifact reduction, and quantitative imaging.

Gamma & Compton Imaging Systems
Development of miniaturized Compton cameras and gamma imaging solutions for intraoperative and endoscopic use.

Multimodal Imaging Platforms
Integration of CT, gamma imaging, and MRI into unified acquisition and reconstruction frameworks.

Computational Imaging & Reconstruction
Physics-based and data-driven reconstruction methods for sparse, noisy, and heterogeneous data.

System Vision

Our research aims at breaking classical modality boundaries.

We develop imaging systems that:

• Combine anatomical and functional information in a single setup
• Operate with minimal infrastructure
• Enable real-time and intraoperative imaging
• Scale from preclinical systems to clinical translation

This includes:

• Compact hybrid CT/gamma systems
• Endoscopic and laparoscopic gamma imaging
• Mobile or infrastructure-independent imaging solutions

Applications

• Oncology and molecular imaging
• Surgical guidance and intraoperative imaging
• Dental and high-resolution imaging
• Preclinical and biomaterial research

ACTIV Group Members

Spectral CT vs. dual-energy CT