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Becker Laboratory

Genetics / Epigenetics in Neoplasias and Blood Disorders

Scientific focus

Our research focus is the investigation of genetics and epigenetics of myeloid disorders and solid cancers. Genetic and epigenetic aberrations drive cancerogenesis and shape the clonal composition of malignancies. Intracellular mechanisms and the clonal composition are crucial for sensitivity or resistance of a given cancer treatment. In addition, aberrant myeloid-derived blood cells have been recognized as important contributors to the pathogenesis of solid cancers and other non-hematologic disorders. Our overarching goal is to better understand the genetic/epigenetic clonal architecture of cancers and blood disorders and the changes under treatment, and to identify biological mechanisms and predictive markers associated with primary or secondary resistance to treatment, and to use this knowledge to improve patient care.

Open Positions

Applications are always welcome! PhD and MD student positions are available in projects focusing on epigenetic biomarkers and treatment. Please send your email to heiko.becker@uniklinik-freiburg.de


Principal Investigator

Prof. Dr. Heiko Becker


      Sekretariat: Frau Solveig Kapfer

 +49 (0) 761 270-32888

 +49 (0) 761 270-96-36970


Lab Members

  • Dr. Jan Mitschke, PhD
  • Inga Hund, Phd student
  • David Uhl, MD student
  • Dr. Valerie Hupfer, MD
  • Dr. Rebeka Javorniczky, MD

Former members

  • Dr. Maria Alejandra Parigiani, Postdoc
  • Dr. Julianne Mendi Muthinja, Postdoc
  • Jean Christoph Niemöller, PhD student
  • Dr. Juliane Palmer, PhD student
  • Sabine Bleul, technician
  • Dr. Nathalie Renz, MD student
  • Dr. Janika Rhein, MD student

     •  Bundesministerium für Bildung und Forschung (Cluster4Future nanodiag BW (www.nanodiag.de)

         •   Deutsche Forschungsgemeinschaft (Klinische Forschungsgruppe 2674)

         •  Baden-Württemberg Stiftung (Monogram)

                                                           •  Forschungskommission Universität Freiburg

                                                  Former funding

         •  Deutsche José Carreras Leukämie-Stiftung


     •   Böhringer Ingelheim Stiftung

         •  Deutsche Krebshilfe