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Klinik für Innere Medizin IHämatologie, Onkologie und Stammzelltransplantation

Becker Laboratory

Genetics / Epigenetics in Neoplasias and Blood Disorders

Scientific focus

Our research focus is the investigation of genetics and epigenetics of myeloid disorders and solid cancers. Genetic and epigenetic aberrations drive cancerogenesis and shape the clonal composition of malignancies. Intracellular mechanisms and the clonal composition are crucial for sensitivity or resistance of a given cancer treatment. In addition, aberrant myeloid-derived blood cells have been recognized as important contributors to the pathogenesis of solid cancers and other non-hematologic disorders. Our overarching goal is to better understand the genetic/epigenetic clonal architecture of cancers and blood disorders and the changes under treatment, and to identify biological mechanisms and predictive markers associated with primary or secondary resistance to treatment, and to use this knowledge to improve patient care.

Team

  • Dr. Valerie Hupfer, MD
  • Dr. Rebeka Javorniczky, MD
  • David Uhl, MD student

Former members

  • Dr. Maria Alejandra Parigiani, Postdoc
  • Sabine Bleul, technician
  • Nathalie Renz, MD student
  • Janika Rhein, MD student
  • Dr. Juliane Stosch, PhD student

  • Deutsche Forschungsgemeinschaft
  • Baden-Württemberg Stiftung
  • Deutsche José Carreras Leukämie-Stiftung

Former funding

  • Böhringer Ingelheim Stiftung
  • Deutsche Krebshilfe