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Klinik für Innere Medizin IHämatologie, Onkologie und Stammzelltransplantation

Illert Laboratory

Molekulare Onkologie - Signaltransduktion onkogener Tyrosininasen

Scientific focus

  • Signal Transduction of oncogenic Tyrosine kinases
  • Crosstalk between the Stress-pathways: DNA-Repair -Fanconi and Apoptosis
  • Immune escape and attack of T-NHLs
  • Genetic defined Murine Mouse models
  • Precision oncology with the Molecular Tumor board
  • Interdisciplinary early clinical trials

  • 10/2020
    Salome was awarded the Sieglinde-Welker-DGHO-Stipendium
  • 07/2020 
    Mehtap was awarded the SUCCESS-Fellowship 2020
  • 06/2020
    Lena was awarded the Advanced Clinician Scientist Program of the DGIM
  • 05/2020
    Nathalie was awarded the José Carreras-DGHO-Promotionsstipendium  
  • 03/2020
    Stefanie´s Paper on a new FANCONI Anemia associating protein and Inherited Bone Marrow Failure Gene NIPA was accepted in JCI 
  • 02/2020
    Teresa´s Work on CD30 in ALCL was accepted fpr presentation at AACR 2020 in San Diego
  • 02/2020
    Stefanie´s and Cathy´s Paper on lymphoma initiating cells in NPM-ALK-positive T-cell Lymphoma was accepted for Publication in LEUKEMIA 
  • 10/2019
    Stefanie was awarded in Berlin the DGHO YOUNG MASTER AWARD 2019
  • 10/2019
    Welcome to Salome, Nathalie and Pauline as new MD students in the Lab
  • 08/2019
    Anina´s paper on NPM-ALK induced phosphorylation of NIPA was accepted in Int J of Mol Sci 
  • 07/2019
    Yu´s Paper on Autophagy in CML was accepted in Haematologica 
  • 06/2019
    Alina´s and Tony´s paper on the cooperation of FLT3-TKD with mutant NPM in AML was accepted for publication BLOOD 
  • 04/2019
    Linda was awarded the 3-year Clinician Scientist IMMPACT Fellowship
  • 02/2019
    Welcome to Linda as M.D. Post Doc and Clinician Scientist in the Lab

Principal Investigator

PD Dr. Lena Illert

Telefon +49 (0) 761 270-71760
Telefax +49 (0) 761 270-71770
lena.illert@uniklinik-freiburg.de

Curriculum vitae


Salome Yacob
Med. Doktorandin
salome.yacob@uniklinik-freiburg.de

Kerstin Stock
Master Student Molecular Medicine
kerstin.stock@uniklinik-freiburg.de

 

Teresa Poggio
Biotechnologin
teresa.poggio@uniklinik-freiburg.de

  • Dr. Stefanie Kreutmair
    Present Position: Post Doc Becher Lab, Zürich, Switzerland.
    Former MD-Student, Post Doc and Clinican Scientist Illert Lab
  • Dr. Alina Rudorf-Müller
    Present Position: Associate Consultant Thescon GmbH.
    Former PhD Student and PostDoc Illert Lab
  • Dr. Chuanjiang, Yu
    Present Position: Post Doc Dalla-Favera Lab, Columbia University, New York, USA.
    Former PhD Student Illert Lab
  • Dr. Lena Lippert
    Present Position: Physician, Charite Berlin.
    Former MD-Student in the Illert Lab
  • Dr. Anina Gengebacher
    Present Position: Physician Urology; Klinikum Offenburg.
    Former MD-Student Illert Lab
  • Dr. Michael Zech
    Present Position: Clinician Scientist Neurology TU Munich.
    Former MD-Student Illert Lab
  • Tamina Rückert
    Present Position: PhD Student Köhler Lab, Freiburg.
    Former Master Student Illert Lab
  • Melissa Zwick
    Present Position: PhD Student Köhler Lab, Freiburg.
    Former Master Student Illert Lab

  • Prof. Dr. Ian Frew, BIOSS, Klinik für Innere Medizin 1, Freiburg
  • Prof. Dr. Sven Diederichs; DKTK, Division of Cancer Research, Klinik für Thoraxchirurgie, Freiburg
  • Prof. Dr. Matthias Eder, DKTK, Department für Radiologische Diagnostik und Therapie, Freiburg
  • Prof. Dr. Stefan Fröhling, NCT Heidelberg
  • Prof. Dr. Dr. M. Börries, Instituts für Medizinische Bioinformatik und Systemmedizin, Freiburg
  • Dr. Nina Cabezas Wallscheid, MPI Freiburg
  • Prof. C. Niemeyer,  Zentrum für Kinderheilkunde und Jugendmedizin, Freiburg
  • PD Dr. M. Erlacher, Zentrum für Kinderheilkunde und Jugendmedizin, Freiburg
  • Prof. P. Henneke, CCI und Zentrum für Kinderheilkunde und Jugendmedizin, Freiburg
  • Prof. Dr. A. Schmitt-Gräff (Pathologisches Institut, Universitätsklinikum Freiburg)
  • Prof. T. Brummer, Institut für Molekulare Medizin und Zellforschung, Freiburg
  • Prof. Dr. S. Laßmann, Prof. Werner, Abteilung Pathologie, Universitätsklinik Freiburg
  • Prof. R. Zeiser, Klinik für Innere Medizin 1, Freiburg
  • Prof. Dr. Philip Meyer, Klinik für Nuklear Medizin Freiburg  
  • Prof Dr. R. Oostendorp, Universitätsklinik rechst der Isar, München
  • Prof Dr. Florian Bassermann, Universitätsklinik rechst der Isar, München
  • Prof Dr. S. Turner, University of Cambridge, UK
  • Prof. M. Wasik, Fox Chase Cancer Center, Philadelphia, USA
  • Prof. Schindler, Institut für Humangenetik, Biozentrum Universitätsklinik Würzburg

PubMed

  1. Kreutmair S, Erlacher M, Andrieux G, Istvanffy R, Rudorf A, Zwick M, Kawaguchi H, Follo M, Klingeberg, C Wlodarski M, Baumann I, Mueller TA, Pfeifer D, Kulinski M, Rudelius M, Lemeer S, Kuster B, Dierks C, Peschel C, Cabesaz-Wallscheid N, Duque-Afonso J, Zeiser R, Cleary ML, Schindler D, Schmitt-Graeff A, Boerries M, Niemeyer CM, Oostendorp RAJ, Duyster J, Illert AL.
    Loss of the Fanconi Anemia-Associated Protein NIPA causes Bone Marrow Failure.
    Journal of Clinical Investigation 2020 accepted (02/2020)
  2. Kreutmair S, Klingeberg C, Poggio T, Andrieux G, Keller A, Miething C, Follo M, Pfeifer D, Shoumariyeh K, Lengerke C, Gonzalez-Menendez I, Fend F, Zeiser R, Turner SD, Quintanilla-Martinez L, Boerries M, Duyster J, Illert AL.
    Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model;
    Leukemia 2020 accepted (02/2020)
  3. Rudorf A, Müller T, Klingeberg C, Kreutmair S, Poggio T, Gorantla S, Rückert T, Schmitt-Gräff A, Gengenbacher A, Paschka P, Baldus C, Vassiliou GS, Bradley A, Duyster J and Illert AL.
    NPM1c alters FLT3-D835Y localization and signalling in acute myeloid leukemia.
    Blood 2019 Jul 25;134(4):383-388
  4. Yu C, Gorantla SP, Mueller TA, Kreutmair S, Rudorf A, Albers C, Lippert LJ, Yue Z, Follo M Huber TB, Duyster J, Illert AL.
    Phosphorylation of Beclin-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia.
    Haematologica 2019 haematol 21202710.3324
  5. Gengenbacher A, Rudorf A, Poggio T, Grässel L, Dumit V, Kreutmair S, Lippert L, Duyster J, Illert AL.
    Proteomic Phosphosite Analysis Identified Crucial NPM-ALK-Mediated NIPA Serine and Threonine Residues.
    Int J Mol Sci 2019 20;20(16)
  6. Müller TA, Grundler R, Istvanffy R, Rudelius M, Hennighausen L, Illert AL*, Duyster J*.
    Lineage specific STAT5 target gene activation in hematopoietic progenitor cells predicts the FLT3+-mediated leukemic phenotype.
    Leukemia 2016 Aug;30(8):1725-33
  7. Illert AL*, Albers C, Kreutmair S, Leischner H, Peschel C, Miething C, Duyster J.
    Grb10 is involved in BCR-ABL positive leukemia in mice.
    Leukemia 2015 Apr;29(4):858-68 *corresponding author
  8. Illert AL*, Seitz A, Rummelt C, Kreutmair S,  Engh RA, Goodstal S, Peschel C, Duyster J, von Bubnoff N.
    Inhibition of Aurora kinase B is necessary and sufficient for biologic activity of the dual inhibitors of BCR-ABL and Aurora kinases AS703569 and PHA-739358 in BCR-ABL transformed cells.
    PLoS One 2014 Nov 26;9(11):e112318.doi *corresponding author
  9. Illert AL, Kawaguchi H, Antinozzi C, Bassermann F, Quintanilla de Fend L, von Klitzing C, Hiwatari M, Peschel C, de Rooij DG, Morris SW, Barchi M, Duyster J.
    Targeted inactivation of nuclear interaction partner of ALK (NIPA) disrupts meiotic prophase.
    Development 2012 139 (14):2523-34
  10. Illert AL, Zech M, Moll C, Albers C, Kreutmair S, Peschel C, Bassermann F and Duyster J.
    Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M.
    J Biol Chem 2012 287, 37997-38005
  11. Eskelinen EL*, Illert AL*, Tanak a Y, Schwarzmann G, Blanz J, Von Figura K and Saftig P. 
    Role of LAMP-2 in lysosome biogenesis and autophagy.
    Mol Biol Cell 2002 13, 3355-3368  *shared 1st authorship

2020-2022 Advanced Clinician Scientist Stipendium of the German Society of Internal Medicine

 

2019 Young-Investigator-Award of the German Society of Hematology Oncology (First author: Stefanie Kreutmair, Senior author: Lena Illert)

 

2018 DGHO-Poster Award “AML Biology” (First author: Alina Rudorf, Senior author: Lena Illert)

 

04/2018 Visiting professorship Penn University, Philadelphia, USA

 

2017 Eleonore und Fritz Hodeige Preis

 

2015 – 2018 Brigitte-Schlieben-Langen-Fellow by the Government for Science, Research and Arts of Baden-Württemberg

 

2017 Prinicipal investigator within the Deutschen Konsortium für Translationale Krebsforschung (DKTK)

 

2015 Mathilde-Wagner-Habilitation-Prize

 

2015 Young-Investigator-Award of the German Society of Hematology Oncology (First author: Stefanie Kreutmair, Senior author: Lena Illert)

 

2013 EIRA-Mentoring Program for Leadership skills of the University of Freiburg

 

2009 – 2013 Abstract Achievement Awards of the American and European Society of Hematology (ASH and EHA)

 

2005 – 2007 Travel awards for the American Society of Hematology (ASH) meeting

 

1999 – 2001 Fellowship German research Foundation (DFG) Graduate College 80