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Klinik für Innere Medizin IHämatologie, Onkologie und Stammzelltransplantation

Illert Laboratory

Molekulare Onkologie - Signaltransduktion onkogener Tyrosininasen

Wir suchen Mitarbeiter*innen!


  • Student*innen der Medizin, Molekularen Medizin, Humanbiologie, Biochemie oder Biologie
  • Technische Assistent*innen

Für weitere Informationen wenden Sie sich bitte an Dr. Lena Illert ⇒ lena.illert@uniklinik-freiburg.de



Pauline Adelberger
Med. Doktorandin
pauline.adelberger@uniklinik-freiburg.de
Nathalie Bechtler
Med. Doktorandin
nathalie.bechtler@uniklinik-freiburg.de
Dr. Linda Gräßel
Clinician Scienstist
linda.graessel@uniklinik-freiburg.de
Salome Yacob
Med. Doktorandin
salome.yacob@uniklinik-freiburg.de
Dr. Alina Müller-Rudorf
Post Doc
alina.mueller-rudorf@uniklinik-freiburg.de
Stefanie Kreutmair
Clinician Scienstist
stefanie.kreutmair@uniklinik-freiburg.de
Teresa Poggio
Biotechnologin
teresa.poggio@uniklinik-freiburg.de
Sabina Schaberg
MTA
sabina.schaberg@uniklinik-freiburg.de

  • Signal Transduction of oncogenic Tyrosine kinases
  • Crosstalk between the Stress-pathways: DNA-Repair -Fanconi and Apoptosis
  • Immune escape and attack of T-NHLs
  • Genetic defined Murine Mouse models
  • Precision oncology with the Molecular Tumor board
  • Interdisciplinary early clinical trials  

  • Prof. Dr. Dr. M. Börries, Instituts für Medizinische Bioinformatik und Systemmedizin, Freiburg
  • Dr. Nina Cabezas Wallscheid, MPI Freiburg
  • Prof. C. Niemeyer,  Zentrum für Kinderheilkunde und Jugendmedizin, Freiburg
  • PD Dr. M. Erlacher, Zentrum für Kinderheilkunde und Jugendmedizin, Freiburg
  • Prof. P. Henneke, CCI und Zentrum für Kinderheilkunde und Jugendmedizin, Freiburg
  • Prof. Dr. A. Schmitt-Gräff (Pathologisches Institut, Universitätsklinikum Freiburg)
  • Prof. T. Brummer, Institut für Molekulare Medizin und Zellforschung, Freiburg
  • Prof. Dr. S. Laßmann, Prof. Werner, Abteilung Pathologie, Universitätsklinik Freiburg
  • Prof. R. Zeiser, Klinik für Innere Medizin 1, Freiburg
  • Prof. Dr. Philip Meyer, Klinik für Nuklear Medizin Freiburg  
  • Prof Dr. R. Oostendorp, Universitätsklinik rechst der Isar, München
  • Prof Dr. Florian Bassermann, Universitätsklinik rechst der Isar, München
  • Prof Dr. S. Turner, University of Cambridge, UK
  • Prof. M. Wasik, Fox Chase Cancer Center, Philadelphia, USA
  • Prof. Schindler, Institut für Humangenetik, Biozentrum Universitätsklinik Würzburg

⇒ PubMed


  1. Kreutmair S, Erlacher M, Andrieux G, Istvanffy R, Rudorf A, Zwick M, Kawaguchi H, Follo M, Klingeberg, C Wlodarski M, Baumann I, Mueller TA, Pfeifer D, Kulinski M, Rudelius M, Lemeer S, Kuster B, Dierks C, Peschel C, Cabesaz-Wallscheid N, Duque-Afonso J, Zeiser R, Cleary ML, Schindler D, Schmitt-Graeff A, Boerries M, Niemeyer CM, Oostendorp RAJ, Duyster J, Illert AL.
    Loss of the Fanconi Anemia-Associated Protein NIPA causes Bone Marrow Failure.
    Journal of Clinical Investigation 2020 accepted (02/2020)
  2. Kreutmair S, Klingeberg C, Poggio T, Andrieux G, Keller A, Miething C, Follo M, Pfeifer D, Shoumariyeh K, Lengerke C, Gonzalez-Menendez I, Fend F, Zeiser R, Turner SD, Quintanilla-Martinez L, Boerries M, Duyster J, Illert AL.
    Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model;
    Leukemia 2020 accepted (02/2020)
  3. Rudorf A, Müller T, Klingeberg C, Kreutmair S, Poggio T, Gorantla S, Rückert T, Schmitt-Gräff A, Gengenbacher A, Paschka P, Baldus C, Vassiliou GS, Bradley A, Duyster J and Illert AL.
    NPM1c alters FLT3-D835Y localization and signalling in acute myeloid leukemia.
    Blood 2019 Jul 25;134(4):383-388
  4. Yu C, Gorantla SP, Mueller TA, Kreutmair S, Rudorf A, Albers C, Lippert LJ, Yue Z, Follo M Huber TB, Duyster J, Illert AL.
    Phosphorylation of Beclin-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia.
    Haematologica 2019 haematol 21202710.3324
  5. Gengenbacher A, Rudorf A, Poggio T, Grässel L, Dumit V, Kreutmair S, Lippert L, Duyster J, Illert AL.
    Proteomic Phosphosite Analysis Identified Crucial NPM-ALK-Mediated NIPA Serine and Threonine Residues.
    Int J Mol Sci 2019 20;20(16)
  6. Müller TA, Grundler R, Istvanffy R, Rudelius M, Hennighausen L, Illert AL*, Duyster J*.
    Lineage specific STAT5 target gene activation in hematopoietic progenitor cells predicts the FLT3+-mediated leukemic phenotype.
    Leukemia 2016 Aug;30(8):1725-33
  7. Illert AL*, Albers C, Kreutmair S, Leischner H, Peschel C, Miething C, Duyster J.
    Grb10 is involved in BCR-ABL positive leukemia in mice.
    Leukemia 2015 Apr;29(4):858-68 *corresponding author
  8. Illert AL*, Seitz A, Rummelt C, Kreutmair S,  Engh RA, Goodstal S, Peschel C, Duyster J, von Bubnoff N.
    Inhibition of Aurora kinase B is necessary and sufficient for biologic activity of the dual inhibitors of BCR-ABL and Aurora kinases AS703569 and PHA-739358 in BCR-ABL transformed cells.
    PLoS One 2014 Nov 26;9(11):e112318.doi *corresponding author
  9. Illert AL, Kawaguchi H, Antinozzi C, Bassermann F, Quintanilla de Fend L, von Klitzing C, Hiwatari M, Peschel C, de Rooij DG, Morris SW, Barchi M, Duyster J.
    Targeted inactivation of nuclear interaction partner of ALK (NIPA) disrupts meiotic prophase.
    Development 2012 139 (14):2523-34
  10. Illert AL, Zech M, Moll C, Albers C, Kreutmair S, Peschel C, Bassermann F and Duyster J.
    Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M.
    J Biol Chem 2012 287, 37997-38005
  11. Eskelinen EL*, Illert AL*, Tanak a Y, Schwarzmann G, Blanz J, Von Figura K and Saftig P. 
    Role of LAMP-2 in lysosome biogenesis and autophagy.
    Mol Biol Cell 2002 13, 3355-3368  *shared 1st authorship

AG-Leiterin

PD Dr. Lena Illert

Telefon +49 (0) 761 270-71760
Telefax +49 (0) 761 270-71770
lena.illert@uniklinik-freiburg.de

  • 04/2020  Linda was awarded the 3-year Clinician Scientist IMMPACT Fellowship
     
  • 03/2020  Stefanie´s Paper on a new FANCONI Anemia associating protein and Inherited Bone Marrow Failure Gene NIPA was accepted in JCI 
     
  • 02/2020  Teresa´s Work on CD30 in ALCL was accepted fpr presentation at AACR 2020 in San Diego
     
  • 02/2020  Stefanie´s and Cathy´s Paper on lymphoma initiating cells in NPM-ALK-positive T-cell Lymphoma was accepted for Publication in LEUKEMIA
     
  • 10/2020  Stefanie was awarded in Berlin the DGHO YOUNG MASTER AWARD 2019
     

  • 10/2020  Welcome to Salome, Nathalie and Pauline as new MD students in the Lab
     

  • 08/2019  Anina´s paper on NPM-ALK induced phosphorylation of NIPA was accepted in Int J of Mol Sci
     

  • 07/2019  Yu´s Paper on Autophagy in CML was accepted in Haematologica
     

  • 06/2019  Alina´s and Tony´s paper on the cooperation of FLT3-TKD with mutant NPM in AML was accepted for publication BLOOD
     

  • 02/2019  Welcome to Linda as M.D. Post Doc and Clinician Scientist in the Lab